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首页> 外文期刊>Current Cancer Therapy Reviews >Transcription Factors as Targets for Cancer Therapy: AP-1 a Potential Therapeutic Target
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Transcription Factors as Targets for Cancer Therapy: AP-1 a Potential Therapeutic Target

机译：转录因子作为癌症治疗的目标：AP-1一个潜在的治疗目标

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摘要

The field of cancer therapy is rapidly moving forward with the development of numerous prospective new agents designed to inhibit cellular factors involved in signal transduction, cell proliferation, and the onset of apoptosis. At the core of these biological processes are transcription factors that are the functional mediators of these effects. Transcription factors are the downstream targets of numerous signal transduction pathways that are central to the process of carcinogenesis. The Activator Protein-1 (AP-1) complex is one such factor that has a central role in multiple processes involved in tumorigenesis including proliferation, migration, invasion and metastasis. The focus of this review is, using AP- 1 as a model, to discuss transcription factors as targets for cancer therapy. The feasibility of targeted disruption of AP-1 by various agents such as dominant-negative mutants, small molecule inhibitors, transcription factor decoys (TFD), chemotherapeutic drugs, chemoprevention agents, siRNA and natural products will be explored.
机译：随着许多前瞻性新药的开发，癌症治疗领域正在迅速向前发展，这些新药旨在抑制参与信号转导，细胞增殖和凋亡发生的细胞因子。这些生物学过程的核心是转录因子，它们是这些作用的功能介体。转录因子是许多信号转导途径的下游目标，而这些信号转导对于癌变过程至关重要。激活蛋白-1（AP-1）复合物就是这样一种因子，在涉及肿瘤发生的多个过程（包括增殖，迁移，侵袭和转移）中起着核心作用。这篇综述的重点是使用AP-1作为模型，讨论转录因子作为癌症治疗的靶标。将探讨各种试剂（如显性负突变，小分子抑制剂，转录因子诱饵（TFD），化学治疗药物，化学预防剂，siRNA和天然产物）对AP-1的靶向破坏的可行性。

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