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STRUCTURE BASED AND COMBINATORIALLY SELECTED OLIGONUCLEOSIDE PHOSPHOROTHIOATE AND PHOSPHORODITHIOATE APTAMER TARGETING AP-1 TRANSCRIPTION FACTORS
STRUCTURE BASED AND COMBINATORIALLY SELECTED OLIGONUCLEOSIDE PHOSPHOROTHIOATE AND PHOSPHORODITHIOATE APTAMER TARGETING AP-1 TRANSCRIPTION FACTORS
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机译:靶向AP-1转录因子的基于结构和组合选择的寡聚核苷酸和磷酸硫代磷酸酯
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摘要
The present invention includes composition and methods for making and using acombinatorial library to identify modified thioptamers that bind to, andaffect the immune response of a host animal, transcription factors such as IL-6, NF-KB, AP-1 and the like. Composition and methods are also provided for thetreatment of viral infections, as well as, vaccines and vaccine adjuvants areprovided that modify host immune responses.
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