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首页> 外文期刊>Current Immunology Reviews >Host-Cell Survival and Death During Chlamydia Infection
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Host-Cell Survival and Death During Chlamydia Infection

机译：衣原体感染期间宿主细胞的存活和死亡

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Different Chlamydia trachomatis strains are responsible for prevalent bacterial sexually-transmitted disease and represent the leading cause of preventable blindness worldwide. Factors that predispose individuals to disease and mechanisms by which chlamydiae cause inflammation and tissue damage remain unclear. Results from recent studies indicate that prolonged survival and subsequent death of infected cells and their effect on immune effector cells during chlamydial infection may be important in determining the outcome. Survival of infected cells is favored at early times of infection through inhibition of the mitochondrial pathway of apoptosis. Death at later times displays features of both apoptosis and necrosis, but pro-apoptotic caspases are not involved. Most studies on chlamydial modulation of host-cell death until now have been performed in cell lines. The consequences for pathogenesis and the immune response will require animal models of chlamydial infection, preferably mice with targeted deletions of genes that play a role in cell survival and death.
机译：不同的沙眼衣原体菌株是造成细菌性传播疾病的主要原因，并且是全球可预防失明的主要原因。尚不清楚个体易患疾病的因素以及衣原体引起炎症和组织损伤的机制。最近的研究结果表明，在衣原体感染期间，被感染细胞的延长生存期和随后的死亡以及它们对免疫效应细胞的影响可能对确定结局很重要。通过抑制细胞凋亡的线粒体途径，在感染的早期有利于感染细胞的存活。以后的死亡显示出凋亡和坏死的特征，但是不涉及促凋亡的胱天蛋白酶。迄今为止，大多数关于衣原体调节宿主细胞死亡的研究都是在细胞系中进行的。致病机理和免疫应答的后果将需要衣原体感染的动物模型，优选具有在细胞存活和死亡中起作用的基因的靶向缺失的小鼠。

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