• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current Immunology Reviews >Influence of CD80 and CD86 Co-Stimulation in the Modulation of the Activation of Antigen Presenting Cells
【24h】

Influence of CD80 and CD86 Co-Stimulation in the Modulation of the Activation of Antigen Presenting Cells

机译：CD80和CD86共刺激对抗原呈递细胞激活的调节作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The role of CD80 and CD86 costimulatory molecules is well established in the activation of T cells but not antigen presenting cells. Recently, many reports in literature have demonstrated categorically the influence of CD80 and CD86 in the activation of B cells and dendritic cells. Stimulation via CD80/CD86 in B cells can modulate their proliferation, IgG secretion and expression of pro-apoptotic and anti-apoptotic molecules, nuclear localization of NF-κB p50 subunit, phosphorylation of Rel A (p65) and IκB-alpha and increased oct-2 expression. In case of dendritic cells, it has been shown that signals induced via CD80 and CD86 enhance the production of IL-6 and IFN-γ which in turn, upregulates the expression of the enzyme indolamine 2, 3-dioxygenase that results in tryptophan catabolism and affects T cell proliferation. Interestingly, it has been shown that co-stimulation through CD80 can restrict the survival of lymphomas and can also induce apoptosis in neural stem cells. Consequently, it may be concluded that CD28/CD152-CD80/86 interaction delivers a bi-directional co-stimulation, thereby not only having impact on the function of T cells, but also antigen presenting cells.
机译：CD80和CD86共刺激分子的作用在T细胞而非抗原呈递细胞的活化中得到了很好的确立。近来，许多文献报道已经明确地证明了CD80和CD86对B细胞和树突状细胞的活化的影响。通过B细胞中CD80 / CD86的刺激可以调节其增殖，IgG分泌以及促凋亡和抗凋亡分子的表达，NF-κBp50亚基的核定位，Rel A（p65）和IκB-alpha的磷酸化以及增加的oct -2表达式。对于树突状细胞，已经证明通过CD80和CD86诱导的信号增强了IL-6和IFN-γ的产生，进而上调了吲哚胺2、3-双加氧酶的表达，导致色氨酸分解代谢和影响T细胞增殖。有趣的是，已经表明通过CD80的共同刺激可以限制淋巴瘤的存活，还可以诱导神经干细胞凋亡。因此，可以得出结论，CD28 / CD152-CD80 / 86相互作用提供了双向共刺激，从而不仅对T细胞的功能有影响，而且对抗原呈递细胞也有影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号