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Defining a Role for Mucosal Immunity in the Prevention and Pathogenesis of Respiratory Allergic Diseases

机译：定义粘膜免疫在呼吸道过敏性疾病的预防和发病中的作用

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While it has long been recognized that the mucosal and systemic immune systems function semiindependently, until fairly recently, understanding of aeroallergen hypersensitivities derived principally from studies of systemic immune regulation. Nonetheless, tolerance and hypersensitivities to airborne allergens are likely to be driven primarily, if not exclusively, by immunological events taking place within the lungs and their associated lymphoid tissues. Therefore, this review will focus on the role of the airways in the prevention, development, and treatment of respiratory allergic diseases. I will first consider how the immunological immaturity of infancy may contribute to the genesis of respiratory allergic diseases. Current understanding of the mechanisms that promote airway allergen tolerance and those that mediate CD4 cell differentiation will then be discussed. Subsequent sections will review how airway exposures to allergens and man made and natural adjuvants influence local immune homeostasis and host risk for developing respiratory allergic diseases. Finally, I will consider how interventions that target airway immunity might be utilized for the prevention and treatment of aeroallergen hypersensitivities.
机译：早已认识到粘膜和全身免疫系统的功能是半独立的，直到最近，对气敏变应性超敏反应的了解主要源于全身免疫调节的研究。尽管如此，对空气中过敏原的耐受性和超敏性很可能主要（如果不是唯一的话）是由肺及其相关淋巴组织内发生的免疫学事件驱动的。因此，本文将重点探讨呼吸道在预防，发展和治疗呼吸道过敏性疾病中的作用。我将首先考虑婴儿的免疫学不成熟如何导致呼吸道过敏性疾病的发生。然后将讨论目前对促进气道过敏原耐受性的机制和介导CD4细胞分化的机制的理解。随后的部分将回顾气道接触过敏原，人为和天然佐剂如何影响局部免疫稳态，并增加罹患呼吸道过敏性疾病的风险。最后，我将考虑如何将针对气道免疫的干预措施用于预防和治疗气敏性过敏原。

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