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首页> 外文期刊>Journal of pediatric biochemistry. >Immune system network in allergic diseases during sublingual immunotherapy: The role of oral mucosal tissue
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Immune system network in allergic diseases during sublingual immunotherapy: The role of oral mucosal tissue

机译：舌下免疫治疗过程中过敏性疾病的免疫系统网络：口腔粘膜组织的作用

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摘要

Specific sublingual immunotherapy (SLIT) represents an approach currently available to redirect inappropriate immune response in atopic patients. Since oral mucosal tissue displays high affinity for allergens, it is conceivable that the sublingual administration route might induce immunological tolerance towards allergens involving cells and mediators specific of oral and intestinal mucosa. The presence in oral mucosa of dendritic cells (DCs) which express the high-affinity receptor for immunoglobulin (Ig)E (FceRI) seems to suggest that the generation of T regulatory cells in periphery is orchestrated by a particular subset of DCs. It seems that repeated stimulation of naive CD4 T cells with allogenic immature DCs induce Trl cell maturation. Nevertheless, other cells are involved in this process, such as Toll Like Receptors (TLR), Major Histocompatibility Complex I and II (MHC I and II) and costimulatory molecules, such as CD40, CD 80/B7.1 and CD 86/B7.2. An increase of serum IgG4 and IgA, a reduced number of inflammatory cells infiltrating target organs, as well as a reduction of eosinophilic cationic protein and a T cell suppression in the peripheral blood also occur with SLIT. All these molecules orchestrate the immune network within the regional immune system, recreating a favourable environment for the induction of tolerance operated by SLIT.
机译：特定的舌下免疫疗法（SLIT）代表目前可用于重定向不恰当的免疫应答的方法可用于特应患者。由于口腔粘膜组织对过敏原表现出高亲和力，因此可以想到舌下给药途径可能会促使涉及细胞和肠粘膜特异性细胞和介质的过敏原的免疫耐受性。表达免疫球蛋白（Ig）E（Fceri）的高亲和力受体的树突细胞（DCS）中的存在似乎表明，通过特定DC的特定子集策划了周边的T调节细胞的产生。似乎重复刺激天真CD4 T细胞与同种异体未成熟DCS诱导TRL细胞成熟。然而，其他细胞参与该方法，例如受体（TLR），主要组织相容性综合体I和II（MHC I和II）和共刺激分子，如CD40，CD 80 / B7.1和CD 86 / B7 .2。血清血清IgG4和IgA的增加，渗透靶器官的减少数量，以及嗜酸性阳离子蛋白的还原和外周血中的T细胞抑制也发生在狭缝。所有这些分子在区域免疫系统内协调免疫网络，为狭缝运营的耐受性的诱导进行良好的环境。

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