• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current Immunology Reviews >Hepatitis C Virus and Dendritic Cells
【24h】

Hepatitis C Virus and Dendritic Cells

机译：丙型肝炎病毒和树突状细胞

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A majority of hepatitis C virus (HCV) infected individuals become chronically infected. There are approximately 175 million patients chronically infected with HCV worldwide. Multispecific and vigorous cellular immune responses against HCV antigens have been suggested to play a significant role in viral clearance. Patients with chronic HCV are unable to prime and/or maintain vigorous T cell responses which are required to clear the body of the viral infection. Dendritic cells (DCs) are the professional antigen presenting cells which likely play a dominant role in priming and maintaining vigorous T cell responses in HCV infection. Furthermore, inefficient DCs function may play an important role in progression to chronicity in HCV infection. A number of reports have been published examining the functional and phenotypic impairment of dendritic cells in chronic HCV infection. However, these reports are difficult to reconcile. In this article, studies examining the role and modulation/regulation of dendritic cells in HCV infection will be discussed. These elucidations are extremely important for the rational design of vaccine and/or immunotherapy strategies for chronic HCV infection.
机译：大多数感染丙型肝炎病毒（HCV）的人都被慢性感染。全世界大约有1.75亿慢性感染HCV的患者。已提出针对HCV抗原的多特异性和强力细胞免疫应答在病毒清除中起重要作用。患有慢性HCV的患者无法引发和/或维持清除体内病毒感染所需的剧烈T细胞反应。树突状细胞（DC）是专业的抗原呈递细胞，可能在HCV感染中引发和维持强烈的T细胞应答中起主要作用。此外，无效的DC功能可能在HCV感染的慢性发展中起重要作用。已经发表了许多报告，研究了慢性HCV感染中树突状细胞的功能和表型损伤。但是，这些报告很难调和。在本文中，将讨论研究检查树突状细胞在HCV感染中的作用和调节的研究。这些说明对于合理设计用于慢性HCV感染的疫苗和/或免疫疗法至关重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号