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首页> 外文期刊>Cytology and genetics >The Downregulation of the Miniature Gene Does Not Replicate Miniature Loss-of-Function Phenotypes in Drosophila melanogaster Wing to the Full Extent
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The Downregulation of the Miniature Gene Does Not Replicate Miniature Loss-of-Function Phenotypes in Drosophila melanogaster Wing to the Full Extent

机译:微型基因的下调不会复制果蝇翼中的微型功能丧失表型到最大程度。

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摘要

During maturation Drosophila wing epithelial cells undergo number of changes due to processes, which take place in the wing of the newly emerged fly, among which epithelial-to-mesenchymal transition (EMT) and apoptosis are pivotal. It is considered that neurohormone bursicon is responsible for their triggering. In turn, extracellular matrix protein Miniature is also essential for proper progress of apoptosis and, presumably, EMT. In accordance with our previously proposed hypothesis, Miniature and bursicon form stabilizing/accumulative complexes, which are able to diffuse freely within Drosophila wing, in such a way con-stitutively promoting enough concentrations of the maturation triggering signal. Here we tried to come to confirmation of our hypothesis from the other side, using UAS/GAL4 system and RNAi-silencing techniques.
机译:在成熟过程中,果蝇翅上皮细胞由于过程而发生许多变化,这些变化发生在新出现的果蝇的翅中,其中上皮-间质转化(EMT)和凋亡是关键的。人们认为神经激素bursicon触发了它们。反过来,细胞外基质蛋白缩微对于细胞凋亡和可能的EMT的正常进程也必不可少。根据我们先前提出的假设,微型和bursicon形成稳定/积累的复合物,它们能够以果断方式促进足够浓度的成熟触发信号在果蝇翼内自由扩散。在这里,我们尝试使用UAS / GAL4系统和RNAi沉默技术从另一方面验证我们的假设。

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  • 来源
    《Cytology and genetics》 |2013年第2期|124-127|共4页
  • 作者单位

    Department of Pharmacology and Toxicology, University of Lausanne, Switzerland,Department of General and Molecular Genetics, Taras Shevchenko National University of Kyiv, Educational and Scientific Centre "Institute of Biology ", Ukraine;

    Department of Pharmacology and Toxicology, University of Lausanne, Switzerland,Institute of Protein Research, Russian Academy of Sciences, Pushchino, Russia;

    Department of General and Molecular Genetics, Taras Shevchenko National University of Kyiv, Educational and Scientific Centre "Institute of Biology ", Ukraine;

    Department of General and Molecular Genetics, Taras Shevchenko National University of Kyiv, Educational and Scientific Centre "Institute of Biology ", Ukraine;

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