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Expression of Genes Belonging to the IGF-System in Glial Tumors

机译：属于IGF系统的基因在胶质瘤中的表达

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摘要

Increased expression of the insulin-like growth factor (IGF) family members, IGF1, IGF2, their receptors and binding proteins, or combinations thereof has been documented in various malignancies including gliomas. The results of multiple investigations suggest that the IGFs can play a paracrine and/or autocrine role in promoting tumor growth in situ during tumor progression but that these roles may vary depending on the tissue of origin. Enhanced IGF1 expression was not found in glioblastomas and it was supposed that IGF1 participation in the development of glial tumors may be substituted by protein products of highly expressed other genes, also participating in PI3Kand MAPK pathways. Increased expression of IGF-binding protein genes in brain tumors makes the picture even more complicated. As other binding proteins, IGFBPs regulate the activity of their ligands by prolonging their half-life. The discrepancies arising from conflicting evidence on the results obtained by different laboratories in human gliomas are discussed. Our data highlight the importance of viewing the IGF-related proteins as a complex multifactorial system and show that changes in the expression levels of any one component of the system, in a given malignancy, should be interpreted with caution. As IGF targeting for anticancer therapy is rapidly becoming clinical reality, an understanding of this complexity is very timely.
机译：胰岛素样生长因子（IGF）家族成员，IGF1，IGF2，它们的受体和结合蛋白或其组合的表达增加已在包括神经胶质瘤在内的各种恶性肿瘤中得到记录。多项研究的结果表明，IGF可以在肿瘤进展过程中在促进原位肿瘤生长中发挥旁分泌和/或自分泌作用，但这些作用可能会因来源组织而异。在胶质母细胞瘤中未发现增强的IGF1表达，并且认为IGF1参与神经胶质瘤的发展可能被高表达的其他基因的蛋白质产物替代，也参与PI3K和MAPK途径。 IGF结合蛋白基因在脑肿瘤中表达的增加使情况更加复杂。作为其他结合蛋白，IGFBP通过延长其半衰期来调节其配体的活性。讨论了由不同实验室在人脑胶质瘤中获得的结果相互矛盾的证据引起的差异。我们的数据强调了将IGF相关蛋白视为复杂的多因素系统的重要性，并表明在给定的恶性肿瘤中，系统中任何一种组分的表达水平变化均应谨慎解释。随着IGF靶向抗癌治疗正迅速成为临床现实，对这种复杂性的了解非常及时。

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  • 来源
    《Cytology and genetics》 |2011年第5期|p.303-317|共15页
  • 作者

    V. V. Dmitrenko; V. M. Kavsan; O. I. Boyko; V. I. Rymar; A. A. Stepanenko; O. V. Balynska; T. A. Mausheva; V. D. Rozumenko; Y. P. Zozulya;

  • 作者单位

    Institute of Molecular Biology and Genetics, Kyiv, Ukraine;

    Institute of Molecular Biology and Genetics, Kyiv, Ukraine;

    Institute of Molecular Biology and Genetics, Kyiv, Ukraine;

    Institute of Molecular Biology and Genetics, Kyiv, Ukraine;

    Institute of Molecular Biology and Genetics, Kyiv, Ukraine;

    Institute of Molecular Biology and Genetics, Kyiv, Ukraine;

    A. P. Romodanov Institute of Neurosurgery, Kyiv, Ukraine;

    A. P. Romodanov Institute of Neurosurgery, Kyiv, Ukraine;

    A. P. Romodanov Institute of Neurosurgery, Kyiv, Ukraine;

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