• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytology and genetics >The Role of Genetic Determinant in the Development of Severe Perinatal Asphyxia
【24h】

The Role of Genetic Determinant in the Development of Severe Perinatal Asphyxia

机译：遗传决定因素在严重围产期窒息发展中的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The frequency of GSTT1 and GSTM1 gene deletion polymorphism was determined in a case-con trol study of full-term Ukrainian newborns including patients with perinatal asphyxia. Multiplex polymerase chain reaction was used for genotyping 245 full-term newborns. The investigated full-term newborns with perinatal asphyxia were subdivided in the subgroups depending of severity of perinatal asphyxia and neonatal outcome. No significant differences in allele frequencies of homozygous null genotypes of GSTT1 and GSTM1 gene were detected among newborns with moderate perinatal asphyxia and healthy control. How ever, association with the development of severe perinatal asphyxia was detected for the deletion polymor phism in GSTT1 gene and the combination of the GSTT1 absent/GSTM1 absent in the newborns. The study shows that severe perinatal asphyxia may develop in the consequence of genetic predisposition to this condi tion as compare with moderate.
机译：GSTT1和GSTM1基因缺失多态性的频率是在一项对包括足周窒息患者的足月乌克兰新生儿进行病例对照研究中确定的。多重聚合酶链反应用于对245名足月新生儿进行基因分型。根据围产期窒息的严重程度和新生儿结局，将所调查的足月窒息足月新生儿分为亚组。在中度围产期窒息新生儿和健康对照组中，GSTT1和GSTM1基因纯合无效基因型的等位基因频率没有显着差异。然而，检测到与严重围产期窒息有关的新生儿GSTT1基因缺失多态性和GSTT1缺失/ GSTM1缺失的组合。研究表明，与中度相比，这种情况的遗传易感性可能导致严重的围产期窒息。

著录项

  • 来源
    《Cytology and genetics》 |2010年第5期|p.294-299|共6页
  • 作者

    N. G. Gorovenko; Z. I. Rossokha; S. V. Podolskaya; V. I. Pokhylko; G. A. Lundberg;

  • 作者单位

    Department of Medical Genetics, National Medical Academy for Post-graduate Education named after P. L. Shupyk, Kyiv;

    rnReference-centre for molecular diagnostic, Ministry of Public Health of Ukraine, Kyiv;

    rnDepartment of Medical Genetics, National Medical Academy for Post-graduate Education named after P. L. Shupyk, Kyiv;

    rnDepartment of Paediatrics, Ukrainian Stomatology Academy, Poltava;

    rnDivision of Clinical Medicine, School of Health and Medical Sciences, OErebro University, Sweden;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号