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首页> 外文期刊>Biointerphases >Mixed poly (ethylene glycol) and oligo (ethylene glycol) layers on gold as nonfouling surfaces created by backfilling
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Mixed poly (ethylene glycol) and oligo (ethylene glycol) layers on gold as nonfouling surfaces created by backfilling

机译：在金上混合聚（乙二醇）和低聚（乙二醇）层作为回填产生的防污表面

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Backfilling a self-assembled monolayer (SAM) of long poly (ethylene glycol) (PEG) with short PEG is a well-known strategy to improve its potential to resist fouling. Here it is shown, using xray photoelectron spectroscopy, contact angle, and atomic force microscopy, that backfilling PEG thiol with oligo (ethylene glycol) (OEG) terminated alkane thiol molecules results in underbrush formation. The authors also confirm the absence of phase separated arrangement, which is commonly observed with backfilling experiments involving SAMs of short chain alkane thiol with long chain alkane thiol. Furthermore, it was found that OEG addition caused less PEG desorption when compared to alkane thiol. The ability of surface to resist fouling was tested through serum adsorption and bacterial adhesion studies. The authors demonstrate that the mixed monolayer with PEG and OEG is better than PEG at resisting protein adsorption and bacterial adhesion, and conclude that backfilling PEG with OEG resulting in the underbrush formation enhances the ability of PEG to resist fouling.
机译：用短PEG回填长聚乙二醇（PEG）的自组装单层（SAM）是提高其抗结垢潜力的众所周知的策略。此处显示，使用X射线光电子能谱，接触角和原子力显微镜观察，用低聚（乙二醇）（OEG）封端的烷硫醇分子回填PEG硫醇会导致形成刷子。作者还证实了不存在相分离的排列，这在短链烷烃硫醇与长链烷硫醇的SAM进行回填实验中通常会观察到。此外，发现与链烷硫醇相比，添加OEG引起较少的PEG解吸。通过血清吸附和细菌粘附研究测试了表面抗结垢的能力。作者证明，具有PEG和OEG的混合单层在抵抗蛋白质吸附和细菌粘附方面比PEG更好，并得出结论，用OEG回填PEG导致毛刷形成增强了PEG抵抗结垢的能力。

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