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Quantitative analysis of multiple biokinetic models using a dynamic water phantom: A feasibility study

机译：使用动态水体模对多种生物动力学模型进行定量分析：可行性研究

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This study analyzed multiple biokinetic models using a dynamic water phantom. The phantom was custom-made with acrylic materials to model metabolic mechanisms in the human body. It had 4 spherical chambers of different sizes, connected by 8 ditches to form a complex and adjustable water loop. One infusion and drain pole connected the chambers to an auxiliary silicon-based hose, respectively. The radio-active compound solution (TC-99m-MDP labeled) formed a sealed and static water loop inside the phantom. As clean feed water was infused to replace the original solution, the system mimicked metabolic mechanisms for data acquisition. Five cases with different water loop settings were tested and analyzed, with case settings changed by controlling valve poles located in the ditches. The phantom could also be changed from model A to model B by transferring its vertical configuration. The phantom was surveyed with a clinical gamma camera to determine the time-dependent intensity of every chamber. The recorded counts per pixel in each chamber were analyzed and normalized to compare with theoretical estimations from the MATLAB program. Every preset case was represented by uniquely defined, time-dependent, simultaneous differential equations, and a corresponding MATLAB program optimized the solutions by comparing theoretical calculations and practical measurements. A dimensionless agreement (AT) index was recommended to evaluate the comparison in each case. ATs varied from 5.6 to 48.7 over the 5 cases, indicating that this work presented an acceptable feasibility study.
机译：这项研究使用动态水体模分析了多种生物动力学模型。人体模型是用丙烯酸材料定制的，可以模拟人体的代谢机制。它有4个不同大小的球形腔，通过8个沟渠相连，形成一个复杂且可调节的水循环。一个输液和排放极分别将腔室连接到辅助的硅基软管。放射性化合物溶液（标记为TC-99m-MDP）在幻像内部形成了一个密封的静态水回路。由于注入了纯净的饲料水来代替原始溶液，因此该系统模仿了数据采集的代谢机制。测试并分析了五种水循环设置不同的情况，通过控制位于沟渠中的阀杆来改变情况。通过转移模型的垂直配置，模型也可以从模型A更改为模型B。用临床伽马相机对模型进行调查，以确定每个腔室的时间依赖性强度。分析并标准化每个室中每个像素记录的计数，以与MATLAB程序中的理论估计值进行比较。每个预设情况都由唯一定义的，与时间相关的联立微分方程表示，并且相应的MATLAB程序通过比较理论计算和实际测量值来优化解决方案。建议使用无量纲协议（AT）索引来评估每种情况下的比较。在这5个案例中，AT的范围从5.6到48.7，表明这项工作提出了可接受的可行性研究。

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