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首页> 外文期刊>BMC Neurology >Quantitative MRI analysis in children with multiple sclerosis: a multicenter feasibility pilot study
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Quantitative MRI analysis in children with multiple sclerosis: a multicenter feasibility pilot study

机译：多发性硬化症儿童的定量MRI分析：一项多中心可行性先导研究

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Background Pediatric multiple sclerosis (MS) is a rare disorder with significant consequences. Quantitative MRI measurements may provide significant insights, however multicenter collaborative studies are needed given the small numbers of subjects. The goal of this study is to demonstrate feasibility and evaluate lesion volume (LV) characteristics in a multicenter cohort of children with MS. Methods A common MRI-scanning guideline was implemented at six member sites of the U.S. Network of Pediatric MS Centers of Excellence. We included in this study the first ten scans performed at each site on patients meeting the following inclusion criteria: pediatric RRMS within 3?years of disease onset, examination within 1?month of MRI and no steroids 1?month prior to MRI. We quantified T2 number, T2-LV and individual lesion size in a total of 53 MRIs passing quality control procedures and assessed gadolinium-enhancing lesion number and LV in 55 scans. We studied MRI measures according to demographic features including age, race, ethnicity and disability scores, controlling for disease duration and treatment duration using negative binomial regression and linear regression. Results The mean number of T2 lesions was 24.30?±?19.68 (range:1–113) and mean gadolinium-enhancing lesion count was 1.85?±?5.84, (range:0–32). Individual lesion size ranged from 14.31 to 55750.60?mm3. Non-white subjects had higher T2–LV (unadjusted pT2-LV?=?0.028; adjusted pT2-LV?=?0.044), and maximal individual T2-LV (unadjusted pMax?=?0.007; adjusted pMax?=?0.011) than white patients. We also found a trend toward larger mean lesion size in males than females (p?=?0.07). Conclusion Assessment of MRI lesion LV characteristics is feasible in a multicenter cohort of children with MS.
机译：背景小儿多发性硬化症（MS）是一种罕见的疾病，具有重大后果。定量MRI测量可能会提供重要的见识，但是鉴于对象数量较少，需要进行多中心协作研究。本研究的目的是证明多发性MS患儿队列的可行性并评估其病变体积（LV）特征。方法在美国小儿MS卓越中心网络的六个成员站点实施了通用的MRI扫描指南。我们在这项研究中纳入了对满足以下纳入标准的患者在每个部位进行的前十次扫描：发病3年之内的儿科RRMS，MRI的1个月内检查，MRI的1个月内没有类固醇。我们对总共53项通过质量控制程序的MRI中的T2数量，T2-LV和单个病变的大小进行了量化，并在55次扫描中评估了lin增强病变的数量和LV。我们根据人口统计学特征（包括年龄，种族，种族和残疾得分），使用阴性二项式回归和线性回归控制疾病持续时间和治疗持续时间来研究MRI测量。结果T2病变的平均数为24.30？±？19.68（范围：1-113），mean增强病变的平均数为1.85？±？5.84（范围：: 0-32）。单个病变的大小范围为14.31至55750.60？mm 3 。非白人受试者的T2-LV较高（未调整的p T2-LV ？=？0.028;已调整的p T2-LV ？=？0.044），且个体最大T2- LV（未经调整的p Max ？=？0.007;经调整​​的p Max ？=？0.011）比白人患者多。我们还发现，男性的平均病变大小要比女性大（p = 0.07）。结论MRI病变左室特征的评估在多中心MS患儿队列中是可行的。

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