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首页> 外文期刊>BioResearch open access. >Fortified Milk Supplementation Improves Vitamin D Status, Grip Strength, and Maintains Bone Density in Chinese Premenopausal Women Living in Malaysia
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Fortified Milk Supplementation Improves Vitamin D Status, Grip Strength, and Maintains Bone Density in Chinese Premenopausal Women Living in Malaysia

机译：强化牛奶补充剂改善了生活在马来西亚的中国绝经前妇女的维生素D状况，握力并保持了骨密度。

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This study compared the effects of a high-calcium vitamin D fortified milk with added FOS-Inulin versus regular milk on serum parathyroid hormone (PTH), vitamin D status, grip strength (GS), as well as bone density in Chinese premenopausal women over 52 weeks. Premenopausal women ( n =?133), mean age 41 (±5.1) years were randomized into control ( n =?66; regular milk at 500?mg calcium per day) or intervention (Int; n =?67; fortified milk at 1200?mg calcium, 15?μg vitamin D, and 4?g FOS-Inulin per day) groups. Assessments were at baseline, weeks 12, 24, 36, and 52 for changes in vitamin D status, levels of PTH, and GS. Bone mineral densities (BMDs) of the lumbar spine (LS), femoral neck (FN), and whole body (WB) were assessed at baseline and week 52 using GE Lunar iDEXA (GE Healthcare, Madison, WI). At baseline, WB lean mass was positively associated with LS BMD ( r =?0.30, p ?0.001) and FN BMD ( r =?0.33, p =?0.003). Baseline 25(OH) vitamin D3 levels were 48.6 and 53.2?nmol/L ( p =?0.57), respectively, and after the 12 months at 60.8?nmol/L (Int) versus 55.0?nmol/L (controls; p ?0.05 for change from baseline for both groups; no difference between groups at week 52). PTH levels decreased in both groups compared to baseline ( p ?0.001), with no significant difference between groups. WB bone mineral content (BMC) and FN Z-score increased significantly in the Int group ( p =?0.024 and p =?0.008). GS was positively associated with body weight, increasing in both groups over 52 weeks. Fortified milk improved vitamin D status, WB BMC, and Z-score of the FN, while regular milk maintained BMD. In addition, vitamin D status and GS improved.
机译：这项研究比较了高钙维生素D强化牛奶，添加FOS-菊粉和普通牛奶对中国绝经前女性血清甲状旁腺激素（PTH），维生素D状态，握力（GS）以及骨密度的影响52周。绝经前妇女（n = 133），平均年龄41（±5.1）岁，被随机分为对照组（n =？66;普通奶每天500？mg钙）或干预（Int; n =？67;强化奶每天1200？mg钙，15？μg维生素D和4？g FOS-菊粉）。在基线，第12、24、36和52周评估维生素D状态，PTH和GS水平。使用GE Lunar iDEXA（GE Healthcare，Madison，WI）在基线和第52周评估腰椎（LS），股骨颈（FN）和全身（WB）的骨矿物质密度（BMD）。在基线时，WB瘦体重与LS BMD（r =？0.30，p <？0.001）和FN BMD（r =？0.33，p =？0.003）正相关。基线25（OH）维生素D3的水平分别为48.6和53.2nmol / L（p = 0.57），以及12个月后分别为60.8nmol / L（Int）和55.0nmol / L（对照; p <两组的基线变化均≤0.05;第52周时各组之间无差异）。与基线相比，两组的PTH水平均下降（p <0.001），两组之间无显着差异。在Int组中，WB骨矿物质含量（BMC）和FN Z评分显着增加（p =？0.024和p =？0.008）。 GS与体重呈正相关，两组均超过52周。强化牛奶改善了维生素D的状况，WB BMC和FN的Z评分，而普通牛奶则保持了BMD。此外，维生素D状况和GS改善。

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