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Benzodiazepine prescription and length of hospital stay at a Japanese university hospital

机译：苯二氮卓处方和在日本大学医院的住院时间

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Background The relationship between bed days and benzodiazepine prescription (BDZ) in Western countries is inconclusive, and no hospital-based report has documented this phenomenon in Japan. This study was done to assess the association between bed days and BDZ in a Japanese hospital. Methods 21,489 adult patients (55.1% men, mean age 59.9 years old) hospitalized between April, 2005 and December, 2006 were enrolled in the study. Patient age, sex, ICD-10 diagnosis, prescription profile, and days of hospital stay were assessed in 13 non-psychiatric departments using a computer ordering system. Patients prescribed a benzodiazepine during hospitalization were defined as positive. Results Of the total sample, 19.9% were allocated to the benzodiazepine (+) group. Female sex and older age were significant factors associated with benzodiazepine prescription. The median number of bed days was 13, and the likelihood of BDZ significantly increased with the number of bed days, even after controlling for the effects of age, gender, and ICD-10 diagnosis. For example, when the analysis was limited to patients with 50 bed days or longer, the percentage of BDZ (32.7%) was equivalent to that of a report from France. Conclusion Irrespective of department or disease, patients prescribed benzodiazepine during their hospital stay tended to have a higher number of bed days in the hospital. The difference in the prevalence of BDZ between this study and previous Western studies might be attributed to the relatively short length of hospital stay in this study. Because BDZs are often reported to be prescribed to hospitalized patients without appropriate documentation for the indications for use, it is important to monitor the rational for prescriptions of benzodiazepine carefully, for both clinical and economical reasons.
机译：背景技术在西方国家，就寝天数与苯二氮卓类药物处方（BDZ）之间的关系尚无定论，在日本，没有医院的报告记录这种现象。这项研究旨在评估日本一家医院的卧床日与BDZ之间的关联。方法选择2005年4月至2006年12月期间住院的21489例成人患者（男性55.1％，平均年龄59.9岁）。使用计算机订购系统在13个非精神病科中评估了患者的年龄，性别，ICD-10诊断，处方情况和住院天数。住院期间开具苯二氮卓类药物的患者定义为阳性。结果在总样本中，有19.9％被分配到苯二氮卓（+）组。女性和较大年龄是与苯二氮卓处方相关的重要因素。即使控制了年龄，性别和ICD-10诊断的影响，平均卧床天数为13，而BDZ的可能性也随着卧床天数的增加而显着增加。例如，当分析仅限于50张病床或更长病床的患者时，BDZ的百分比（32.7％）等于法国报告的百分比。结论不论部门或疾病，住院期间使用苯二氮卓类药物的患者在医院的卧床天数往往较高。这项研究与以前的西方研究之间的BDZ患病率差异可能是由于该研究的住院时间相对较短。由于据报道BDZ通常在没有适当使用证据的情况下开给住院患者开处方，因此，出于临床和经济原因，仔细监测苯二氮卓处方的合理性很重要。

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