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Effects of antidepressant treatment on heart rate variability in major depression: A quantitative review

机译：抗抑郁药对重度抑郁症心率变异性的影响：定量研究

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Background The literature measuring effects of antidepressant and electroconvulsive therapy (ECT) for major depression on heart rate variability (HRV) in medically well individuals was reviewed. Methods Fourteen studies evaluating HRV were included. Twenty three pre-post or within group comparisons were available. Treatment impact on measures of HRV was pooled over studies. We examined different classes of antidepressants, and for short and long electrocardiogram (ECG) recordings separately. Results Tricyclic antidepressants (TCAs) were associated with declines in most measures of HRV and significant increase in heart rate (HR) in studies with short recording intervals. No significant changes were found for longer recording times. Treatment effects with selective serotonin reuptake inhibitors (SSRIs) were more variable. Short-recording studies revealed a significant decrease in HR and an increase in one HRV measure. In two 24-hour recording studies no significant changes were observed. No relationship between ECT and HRV has been established in the literature. The effects of other drugs are reported. Limitations Few studies measure the effects of treatment of depression on HRV. Existing studies have generally used very small samples, employing a variety of measurements and methodologies. Conclusion We confirm that TCAs are associated with a large decrease in HRV and increase HR. However, data for SSRIs is not clear. Although the effect of SSRIs on HRV is weaker than for TCAs, evidence shows that SSRIs are associated with a small decrease in HR, and an increase in one measure of HRV. The use of TCAs in depression leads to changes in HRV that are associated with increased risk of mortality.
机译：背景综述了有关抗抑郁药和电痉挛疗法（ECT）对重度抑郁症对医学状况良好的人的心率变异性（HRV）的影响的文献。方法包括14项评估HRV的研究。有23个事前比较或小组比较。研究汇总了治疗对HRV的影响。我们检查了不同种类的抗抑郁药，并分别记录了长短心电图（ECG）。结果在记录间隔短的研究中，三环类抗抑郁药（TCA）与大多数HRV测量值下降和心率（HR）显着升高有关。较长的记录时间未发现明显变化。选择性5-羟色胺再摄取抑制剂（SSRIs）的治疗效果变化更大。短记录研究显示，HR显着降低，一项HRV度量值增加。在两项24小时的录音研究中，没有观察到明显的变化。文献中尚未建立ECT与HRV之间的关系。报告了其他药物的作用。局限性很少有研究衡量抑郁症对HRV的影响。现有研究通常使用非常小的样本，并采用各种测量方法。结论我们确认，TCA与HRV的大幅降低和HR升高有关。但是，SSRI的数据尚不清楚。尽管SSRIs对HRV的作用比TCA弱，但证据表明SSRIs与HR的小幅下降和一种HRV的升高有关。在抑郁症中使用TCA会导致HRV的改变，从而导致死亡风险增加。

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