Nucleotide analogue, method of synthesis of nucleotide analogue, use of nucleotide analogue, antiviral pro-nucleotide, pharmaceutical composition

Adam Kraszewski; Joanna Romanowska; Agnieszka Szymańska-Michalak; MIcha? Sobkowski; Jerzy Boryski; Jacek Stawiński; Andrzej Lipniacki; Andrzej Piasek

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Nucleotide analogue, method of synthesis of nucleotide analogue, use of nucleotide analogue, antiviral pro-nucleotide, pharmaceutical composition

机译：核苷酸类似物，核苷酸类似物的合成方法，核苷酸类似物的用途，抗病毒原核苷酸，药物组合物

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摘要

The object of the invention are 1) nucleotide analogues, 2) antiviral pro-nucleotides, 3) a use of nucleotide analogues and pharmaceutical composition, 4) a phosphorylating agent for synthesis of nucleotide analogue, and 5) a method of synthesis of nucleotide analogues. More precisely, the invention applies to the new group of nucleotide analogues and their use in partial or complete inhibition of human immunodeficiency virus (HIV).

机译：本发明的目的是1）核苷酸类似物，2）抗病毒原核苷酸，3）核苷酸类似物和药物组合物的用途，4）用于核苷酸类似物合成的磷酸化剂，和5）核苷酸类似物的合成方法。更确切地，本发明适用于新的核苷酸类似物组及其在部分或完全抑制人免疫缺陷病毒（HIV）中的用途。

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《BioTechnologia》 |2014年第4期|共4页
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Adam Kraszewski; Joanna Romanowska; Agnieszka Szymańska-Michalak; MIcha? Sobkowski; Jerzy Boryski; Jacek Stawiński; Andrzej Lipniacki; Andrzej Piasek;
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中图分类生物工程学（生物技术）;
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专利

1. Preface [Hot Topic: Pro-Nucleotide Development and Delivery of Biologically Active Nucleotide Analogues (Executive Editor: Chris Meier)] [J] . Chris Meier Mini-Reviews in Medicinal Chemistry . 2004,第4期

机译：前言[热门话题：前核苷酸的开发和生物活性核苷酸类似物的提供（执行编辑：克里斯·迈耶）]
2. Bismethylene triphosphate nucleotides of uridine 4-phosphate analogues: A new class of anionic pyrimidine nucleotide analogues [J] . Taylor SD, Mirzaei F, Bearne SL The Journal of Organic Chemistry . 2008,第4期

机译：尿苷4-磷酸类似物的双亚甲基三磷酸核苷酸：一类新的阴离子嘧啶核苷酸类似物
3. Solution Structures of Binary and Ternary Metal Ion Complexes of 9-(5-Phosphonopentyl) adenine (3'-deoxa-PEEA). A Nucleotide A Nucleotide Analogue Related to the Antivirally Active 9-[2-(Phosphonomethoxy) ethyl] adenine (PMEA) [J] . Raquel B. Gomez-Coca, Antonin Holy, Rosario A. Vilaplana, European journal of inorganic chemistry . 2003,第16期

机译：9-（5-Phosphonopentyl）Adenine（3'-deoxa-PEEA）的二元和三元金属离子配合物的溶液结构。与抗病毒活性9- [2-（膦甲氧基）乙基]腺嘌呤（PMEA）相关的核苷酸类似物
4. SYNTHESIS OF NEW TYPES OF POTENTIALLY BIOACTIVE FURANOSYL NUCLEOSIDE AND NUCLEOTIDE ANALOGUES [C] . Andreia Fortuna, Nathalya Mesquita, Glaucius Oliva International Carbohydrate Symposium . 2018

机译：新型潜在生物活性呋喃糖基核苷和核苷酸类似物的合成
5. Synthesis of novel nucleotide analogues based on the traditional and nontraditional bioisosteres. [D] . Shakhmin, Anton. 2014

机译：基于传统和非传统生物等位基因的新型核苷酸类似物的合成。
6. Design synthesis antiviral and cytotoxic evaluation of novel acyclic phosphonate nucleotide analogues with a 56-dihydro-1H-123triazolo45-dpyridazine-47-dione system [O] . Emilia Bankowska, Jan Balzarini, Iwona E. Głowacka, -1

机译：56-二氢-1H- 123三唑45-d哒嗪-47-二酮系统的新型无环膦酸酯核苷酸类似物的设计合成抗病毒和细胞毒性评估
7. Bismethylene Triphosphate Nucleotides of Uridine 4-Phosphate Analogues: A New Class of Anionic Pyrimidine Nucleotide Analogues [O] . -1

机译：脲三磷酸三磷酸核苷酸尿苷4-磷酸酯类似物：新一类阴离子嘧啶核苷酸类似物
8. Template polymerization of nucleotide analogues [R] . Orgel, L. E. 1991

机译：核苷酸类似物的模板聚合

Nucleotide analogue, method of synthesis of nucleotide analogue, use of nucleotide analogue, antiviral pro-nucleotide, pharmaceutical composition

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