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首页> 外文期刊>BMC Complementary and Alternative Medicine >Korean mistletoe ( Viscum album coloratum ) extract regulates gene expression related to muscle atrophy and muscle hypertrophy
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Korean mistletoe ( Viscum album coloratum ) extract regulates gene expression related to muscle atrophy and muscle hypertrophy

机译：韩国槲寄生（Viscum album coloratum）提取物调节与肌肉萎缩和肌肉肥大有关的基因表达

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Background Korean mistletoe ( Viscum album coloratum ) is a semi-parasitic plant that grows on various trees and has a diverse range of effects on biological functions, being implicated in having anti-tumor, immunostimulatory, anti-diabetic, and anti-obesity properties. Recently, we also reported that Korean mistletoe extract (KME) improves endurance exercise in mice, suggesting its beneficial roles in enhancing the capacity of skeletal muscle. Methods We examined the expression pattern of several genes concerned with muscle physiology in C2C12 myotubes cells to identify whether KME inhibits muscle atrophy or promotes muscle hypertrophy. We also investigated these effects of KME in denervated mice model. Results Interestingly, KME induced the mRNA expression of SREBP-1c, PGC-1α, and GLUT4, known positive regulators of muscle hypertrophy, in C2C12 cells. On the contrary, KME reduced the expression of Atrogin-1, which is directly involved in the induction of muscle atrophy. In animal models, KME mitigated the decrease of muscle weight in denervated mice. The expression of Atrogin-1 was also diminished in those mice. Moreover, KME enhanced the grip strength and muscle weight in long-term feeding mice. Conclusions Our results suggest that KME has beneficial effects on muscle atrophy and muscle hypertrophy.
机译：背景技术韩国槲寄生（Viscum album coloratum）是一种半寄生植物，生长在各种树木上，对生物学功能有多种影响，与抗肿瘤，免疫刺激，抗糖尿病和抗肥胖有关。最近，我们还报道了韩国槲寄生提取物（KME）可改善小鼠的耐力运动，表明其在增强骨骼肌容量方面的有益作用。方法我们检查了C2C12肌管细胞中与肌肉生理相关的几个基因的表达模式，以确定KME是抑制肌肉萎缩还是促进肌肉肥大。我们还研究了KME在失神经小鼠模型中的这些作用。结果有趣的是，KME诱导了C2C12细胞中SREBP-1c，PGC-1α和GLUT4的mRNA表达，SREBP-1c，PGC-1α和GLUT4是已知的肌肉肥大的阳性调节因子。相反，KME降低了Atrogin-1的表达，而Atrogin-1直接参与了肌肉萎缩的诱导。在动物模型中，KME减轻了失神经小鼠的肌肉重量的减少。在那些小鼠中，Atrogin-1的表达也减少了。此外，KME增强了长期喂养小鼠的抓地力和肌肉重量。结论我们的结果表明KME对肌肉萎缩和肌肉肥大具有有益的作用。

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