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首页> 外文期刊>BioTechnology: An Indian Journal >E.coli quorum sensing: Appraisal towards curtailing pathogenesis
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E.coli quorum sensing: Appraisal towards curtailing pathogenesis

机译：大肠杆菌群体感应：评估减少发病机理

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摘要

Lower organisms need to communicate with each other to performvarious activities needed for their survival. Microbes have evolved in an astounding manner to develop tailor-made systems to enhance their chances of existence in harsh environmental conditions. They carry out these mechanisms by synchronizing their actions through cell-to-cell communications. These intra-cellular communications bring about a molecular chain of events to spread infection through biofilm formation and virulence. This review shines a spotlight on the entire Escherichia coli quorumsensing network, especiallywith regard to SdiA.As is apparent from earlier studies, SdiA acts as a global regulator for E. coli quorum sensing. We propose that by antagonizing SdiA, virulence and biofilm formation can be contained, thus suppressing pathogenesis of E. coli. As an extension, other Gram-negative microorganisms that have analogous circuits to E. coli can also be constrained.
机译：低等生物需要相互交流以执行其生存所需的各种活动。微生物已经以惊人的方式进化为开发量身定制的系统，以增加其在恶劣环境条件下的生存机会。他们通过通过单元间通信同步其动作来执行这些机制。这些细胞内通讯引起分子事件链，通过生物膜形成和毒力传播感染。这篇评论将重点放在整个大肠杆菌群体感应网络上，尤其是在SdiA方面。从早期研究中可以明显看出，SdiA是大肠杆菌群体感应的全球监管者。我们建议通过拮抗SdiA，可以包含毒性和生物膜形成，从而抑制大肠杆菌的发病机理。作为扩展，也可以限制具有与大肠杆菌相似的回路的其他革兰氏阴性微生物。

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