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首页> 外文期刊>BMC Ophthalmology >Comparing the efficacy of mydriatic cocktail-soaked sponge and conventional pupil dilation in patients using tamsulosin – a randomized controlled trial
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Comparing the efficacy of mydriatic cocktail-soaked sponge and conventional pupil dilation in patients using tamsulosin – a randomized controlled trial

机译：比较坦索罗辛对散瞳混合鸡尾酒海绵和常规瞳孔扩张术对坦索罗辛患者的疗效-一项随机对照试验

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Background A strong association exists between the use of tamsulosin and the occurance of intraoperative floppy iris syndrome. Several methods were advocated to overcome the progressive intraopertive miosis. Our purpose was to investigate the effect of a mydriatic-cocktail soaked cellulose sponge on perioperative pupil diameter in tamsulosin-treated patients undergoing elective cataract surgery. Methods Patients using tamsulosin were dilated either with mydriatic-cocktail soaked sponge (group 1) or with conventional eyedrop regimen (group 2). Control patients not taking any α1 adrenergic receptor inhibtors were also dilated with mydriatic sponge (group 3). In all groups oxybuprocain 0.4%, cocain 4%, tropicamide 1%, phenylephrine 10%, diclophenac 0.1% along with chloramphenicol 0.5% were used preoperatively. Pupil diameter (mm) was measured preoperatively, after nucleus delivery, and before IOL implantation. Adverse effects associated with the use of sponge, minor and major intraoperative complications, the use of iris retractors and operation time were recorded. Differences in general between groups were analyzed with a one way analysis of variance (ANOVA); differences between groups in proportions were assessed by Fisher’s exact test. Results Mean pupil diameter (mm) was preopertively: 7.52?±?1.21, 7.30?±?1.55 and 7.99?±?0.96 (ANOVA: p?=?0.079); after nucleus delivery: 6?±?1.20, 6.29?±?1.12 and 6.52?±?0.81 (ANOVA: p?=?0.123); before IOL implantation: 5.46?±?1.06, 5.83?±?1.09 and 6.17?±?0.89 (ANOVA: p?=?0.0291). No adverse effect related to sponge use was detected. Frequency of minor complications, and iris hook use was similar in the two tamsulosin treated group. Operation time did not differ significantly in the three groups. Conclusion We have found that using a mydriatic cocktail-soaked wick – an alternative way to achieve intraoperative mydriasis for cataract surgery – was as effective and safe as the conventional repeated eyedrops regiment for tamsulosin treated patients. Trial registration Current Controlled Trials ISRCTN37834752
机译：背景坦索罗辛的使用与术中软性虹膜综合征的发生之间存在密切的联系。提出了几种方法来克服进行性术中瞳孔缩小。我们的目的是研究在接受坦索罗辛治疗的择期白内障手术患者中，散瞳鸡尾酒浸泡的纤维素海绵对围手术期瞳孔直径的影响。方法将坦索罗辛患者用散瞳鸡尾酒浸泡的海绵（组1）或常规滴眼液方案（组2）进行扩张。没有服用α 1 肾上腺素能受体抑制剂的对照组患者也用散瞳海绵扩张（第3组）。在所有组中，术前使用奥昔普林0.4％，可卡因4％，托卡酰胺1％，去氧肾上腺素10％，双氯芬酸0.1％和氯霉素0.5％。术前，核交付后和人工晶体植入前测量瞳孔直径（mm）。记录与使用海绵，轻微和主要的术中并发症，虹膜牵开器的使用以及手术时间相关的不良反应。组间一般差异采用单向方差分析（ANOVA）进行分析;两组之间的比例差异通过Fisher的精确检验进行评估。结果术前平均瞳孔直径（mm）为：7.52±±1.21、7.30±1.55和7.99±0.96（ANOVA：p = 0.079）;核交付后：6≤±1.20、6.29±±1.12和6.52±±0.81（方差：p≤0.123）; IOL植入前：5.46±1.06、5.83±1.09和6.17±0.89（方差：p ＝ 0.0291）。没有发现与使用海绵有关的不良影响。在两个坦索罗辛治疗组中，轻微并发症的发生频率和虹膜钩的使用相似。三组的手术时间无明显差异。结论我们已经发现，使用散瞳鸡尾酒浸透的灯芯（一种用于白内障手术的术中散瞳的替代方法）与坦索罗辛治疗的患者常规的常规滴眼液疗法一样有效和安全。试用注册电流对照试验ISRCTN37834752

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