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首页> 外文期刊>BMC Family Practice >Primary care incidence and treatment of four neuropathic pain conditions: A descriptive study, 2002–2005
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Primary care incidence and treatment of four neuropathic pain conditions: A descriptive study, 2002–2005

机译：四种神经性疼痛病症的初级保健发生率和治疗：一项描述性研究，2002-2005年

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Background Between 1992 and 2001 the UK general practice incidence of post-herpetic neuralgia and trigeminal neuralgia declined, whilst the incidence of painful diabetic neuropathy increased. The most common first line treatments were compound analgesics. As therapeutic options have subsequently changed, this study presents updated data on incidence and prescribing patterns in neuropathic pain. Methods A descriptive analysis of the epidemiology and prescription treatment at diagnosis of incident post-herpetic neuralgia (n = 1,923); trigeminal neuralgia (1,862); phantom limb pain (57) and painful diabetic neuropathy (1,444) using computerised UK general practice records (THIN): May 2002 to July 2005. Results Primary care incidences per 100,000 person years observation of 28 (95% confidence interval (CI) 27–30) for post-herpetic neuralgia, 27 (95%CI 26–29) for trigeminal neuralgia, 0.8 (95%CI 0.6–1.1) for phantom limb pain and 21 (95%CI 20–22) for painful diabetic neuropathy are reported. The most common initial treatments were tricyclic antidepressants (post-herpetic neuralgia) or antiepileptics (trigeminal neuralgia and painful diabetic neuropathy) and opioid analgesics (phantom limb pain). The mean number of changes before a stable drug regimen was 1.2 to 1.5 for trigeminal neuralgia, painful diabetic neuropathy and post-herpetic neuralgia, and 2.4 for phantom limb pain. Conclusion The incidence of phantom limb pain and post-herpetic neuralgia are decreasing whilst painful diabetic neuropathy plateaued and trigeminal neuralgia remained constant. Despite more frequent use of antidepressants and antiepileptics for first line treatment, as opposed to conventional non-opioid analgesics, changes to therapy are common before a stable regimen is reached.
机译：背景资料在1992年至2001年期间，英国的全科医师治疗的带状疱疹后神经痛和三叉神经痛的发生率有所下降，而疼痛性糖尿病性神经病的发生率却有所上升。最常见的一线治疗是复合止痛药。随着治疗选择的改变，本研究提供了神经性疼痛的发病率和处方方式的最新数据。方法对描述性疱疹后神经痛（n = 1,923）的流行病学和处方治疗进行描述性分析;三叉神经痛（1,862）;幻肢疼痛（57）和糖尿病性神经病变的疼痛（1,444），使用计算机化的英国一般常规记录（THIN）：2002年5月至2005年7月。结果每100,000人年的初级保健发生率28（95％置信区间（CI）27）–据报道，带状疱疹后神经痛为30（三叉神经痛）（27（95％CI 26–29），幻肢痛为0.8（95％CI 0.6–1.1），疼痛性糖尿病性神经病为21（95％CI 20–22）。 。最常见的初始治疗是三环类抗抑郁药（疱疹后神经痛）或抗癫痫药（三叉神经痛和糖尿病性神经痛）和阿片类镇痛药（幻肢痛）。对于三叉神经痛，糖尿病性神经病和疱疹后神经痛，稳定药物治疗前平均变化数为1.2至1.5，而幻肢痛为2.4。结论幻肢痛和带状疱疹后神经痛的发生率正在降低，而疼痛性糖尿病神经病停滞和三叉神经痛仍保持不变。尽管与传统的非阿片类镇痛药相比，抗抑郁药和抗癫痫药更常用于一线治疗，但在达到稳定的治疗方案之前，通常需要改变治疗方法。

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