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首页> 外文期刊>BMC Surgery >Abdominal aortic aneurysm in patients affected by intermittent claudication: prevalence and clinical predictors
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Abdominal aortic aneurysm in patients affected by intermittent claudication: prevalence and clinical predictors

机译：间歇性lau行症患者的腹主动脉瘤：患病率和临床预测因素

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BackgroundAbdominal aortic aneurysm (AAA) is a frequent cause of death among elderly. Patients affected by lower extremity peripheral arterial disease (LE-PAD) seem to be particularly at high risk for AAA. We aimed this study at assessing the prevalence and the clinical predictors of the presence of AAA in a homogeneous cohort of LE-PAD patients affected by intermittent claudication.MethodsWe performed an abdominal ultrasound in 213 consecutive patients with documented LE-PAD (ankle/brachial index ≤0.90) attending our outpatient clinic for intermittent claudication. For each patient we registered cardiovascular risk factors and comorbidities, and measured neutrophil count.ResultsThe ultrasound was inconclusive in 3 patients (1.4%), thus 210 patients (169 males, 41 females, mean age 65.9 ± 9.8 yr) entered the study. Overall, AAA was present in 19 patients (9.0%), with a not significant higher prevalence in men than in women (10.1% vs 4.9%, p = 0.300). Patients with AAA were older (71.2 ± 7.0 vs 65.4 ± 9.9 years, p = 0.015), were more likely to have hypertension (94.7% vs 71.2%, p = 0.027), and greater neutrophil count (5.5 [4.5 – 6.2] vs 4.1 [3.2 – 5.5] x103/μL, p = 0.010). Importantly, the c-statistic for neutrophil count (0.73, 95% CI 0.60 – 0.86, p =0.010) was higher than that for age (0.67, CI 0.56–0.78, p = 0.017). The prevalence of AAA in claudicant patients with a neutrophil count ≥ 5.1 x103/μL (cut-off identified at ROC analysis) was as high as 29.0%.ConclusionsPrevalence of AAA in claudicant patients is much higher than that reported in the general population. Ultrasound screening should be considered in these patients, especially in those with an elevated neutrophil count.
机译：背景腹主动脉瘤（AAA）是老年人的常见死亡原因。受下肢周围动脉疾病（LE-PAD）影响的患者似乎特别容易发生AAA。本研究旨在评估均发性间歇性lau行的LE-PAD患者队列中AAA的患病率和临床预测指标。方法我们对213例连续的LE-PAD（踝/臂指数）患者进行了腹部超声检查≤0.90）到我们的门诊就诊为间歇性lau行。结果我们对每位患者进行了心血管危险因素和合并症的检测，并测量了中性粒细胞计数。结果3例患者（1.4％）超声检查尚无定论，因此210例患者（男性169例，女性41例，平均年龄65.9±9.8岁）进入研究。总体而言，有19位患者（9.0％）出现AAA，男性患病率并不比女性高（10.1％对4.9％，p = 0.300）。 AAA患者年龄较大（71.2±7.0 vs 65.4±9.9岁，p = 0.015），高血压的可能性更高（94.7％vs 71.2％，p = 0.027），中性粒细胞计数更高（5.5 [4.5 – 6.2] vs 4.1 [3.2 – 5.5] x10 3 /μL，p = 0.010）。重要的是，中性粒细胞计数的c统计量（0.73，95％CI 0.60 – 0.86，p = 0.010）高于年龄（0.67，CI 0.56-0.78，p = 0.017）。在嗜中性粒细胞计数≥5.1 x10 3 /μL（ROC分析中确定的临界值）的克隆性患者中，AAA的患病率高达29.0％。笼统患者的发病率远高于一般人群。这些患者应考虑进行超声筛查，尤其是中性粒细胞计数升高的患者。

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