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首页> 外文期刊>BMC Pulmonary Medicine >Oxygen kinetics during 6-minute walk tests in patients with cardiovascular and pulmonary disease
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Oxygen kinetics during 6-minute walk tests in patients with cardiovascular and pulmonary disease

机译：心血管和肺部疾病患者6分钟步行测试期间的氧气动力学

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Background The 6-Minute Walk Test (6MWT) is representative of daily-life activities and reflects the functional capacity of patients. The change of oxygen uptake (VO2) in the initial phase of low-intensity exercise (VO2 kinetics) can be used to assess submaximal exercise performance of patients. The objective of the following study was to analyse VO2 kinetics in patients with different pulmonary and cardiovascular diseases. In addition, we investigated the extent to which VO2 kinetics at the onset of the 6MWT were associated with exercise capacity, morbidity and mortality. Methods VO2 kinetics of 204 patients and 16 healthy controls were obtained using mobile telemetric cardiopulmonary monitoring during a 6MWT. A new mean response time (MRT) index (wMRT) was developed to quantify VO2 kinetics by correcting MRT for work rate. The differences in wMRT between disease categories as well as the association between wMRT and patients’ exercise capacity and outcome - time to hospitalization/death- were tested. Results The assessment of a robust wMRT was feasible in 86% (244/284) patients. wMRT was increased in patients compared to healthy controls (p Conclusions Submaximal exercise performance of patients is reduced. O2 kinetics at the onset of exercise are associated with exercise capacity in all patients. wMRT was found to be an important prognostic factor in patients with congestive heart failure (CHF), but not with pulmonary diseases.
机译：背景技术6分钟步行测试（6MWT）是日常生活活动的代表，反映了患者的功能能力。低强度运动初期VO 2 动力学过程中摄氧量（VO 2 ）的变化可用于评估患者的次最大运动表现。以下研究的目的是分析不同肺和心血管疾病患者的VO 2 动力学。此外，我们研究了6MWT发作时VO 2 动力学与运动能力，发病率和死亡率之间的关系。方法采用移动遥测心肺监测仪在6MWT期间获得204例患者和16例健康人的VO 2 动力学。开发了一种新的平均反应时间（MRT）指数（wMRT），以通过校正工作率的MRT来量化VO 2 动力学。测试了疾病类别之间的wMRT差异以及wMRT与患者运动能力和结局之间的关联-住院/死亡时间。结果在86％（244/284）患者中评估稳健的wMRT是可行的。与健康对照组相比，患者的wMRT升高（p结论患者的亚最大运动能力下降。运动开始时O 2 动力学与所有患者的运动能力相关。wMRT被认为是一种充血性心力衰竭（CHF）患者的重要预后因素，但不是肺部疾病。

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