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首页> 外文期刊>BMC Infectious Diseases >Rapid identification of Brucella sepsis/osteomyelitis in a 6-year old febrile patient with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry directly from positive blood culture: a case report
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Rapid identification of Brucella sepsis/osteomyelitis in a 6-year old febrile patient with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry directly from positive blood culture: a case report

机译：直接从阳性血液培养物中通过基质辅助激光解吸/电离飞行时间质谱快速鉴定6岁高热患者中的布鲁氏菌败血症/骨髓炎

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摘要

Brucella is high-consequence pathogen and one of the most common seen laboratory- acquired infection pathogens. Quick and accurate detection of the pathogen will be of great important to reducing laboratory- acquired infection. Traditional biomedical reaction based method is time consumption, and mass spectrometry based method greatly reduces time consumption in pathogen identification. In the case presented here, we shared our experience in identification of Brucella directly from positive blood culture with mass spectrometry based method. The patient is a 6-year boy with a history of three weeks fever accompanied with sweating and a pain at right patella. The patient also has a history of thalassemia and blood transfusion was performed previously admitted to our hospital. Two bottles of marrow culture and one bottle of blood culture were positive, and direct mass spectrometry from positive culture material revealed Brucella infection within 1?h. Clinical characters and laboratory findings of the patient presented here might help clinician in non-endemic region to made suspected brucellosis diagnose. Our experience in rapid identification of Brucella from positive blood culture with MALDI-TOF SP could help preventing laboratory-acquired infection of Brucella.
机译：布鲁氏菌是高后果病原体，也是实验室中最常见的感染性病原体之一。快速准确地检测病原体对于减少实验室获得的感染至关重要。传统的基于生物医学反应的方法是耗时的，而基于质谱的方法大大减少了病原体鉴定的时间。在这里介绍的案例中，我们分享了基于质谱的直接从阳性血液培养物中鉴定布鲁氏菌的经验。该患者是一个6岁男孩，有三周发烧史，伴有流汗和右骨疼痛。该患者也有地中海贫血病史，以前曾入我院进行过输血。两瓶骨髓培养物和一瓶血液培养物均为阳性，从阳性培养物进行的直接质谱分析显示布鲁氏菌在1？h内感染。此处介绍的患者的临床特征和实验室检查结果可能有助于非流行地区的临床医生做出疑似布鲁氏菌病的诊断。我们使用MALDI-TOF SP从阳性血液培养物中快速鉴定出布鲁氏菌的经验有助于预防实验室获得的布鲁氏菌感染。

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