• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Breast Cancer: Targets and Therapy >Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells
【24h】

Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells

机译：纳摩尔浓度的血溶性减阻聚合物抑制人乳腺癌细胞的实验转移

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Metastasis is the leading cause of cancer mortality. Extravasation of cancer cells is a critical step of metastasis. We report a novel proof-of-concept study that investigated whether non-toxic blood-soluble chemical agents capable of rheological modification of the near-vessel-wall blood flow can reduce extravasation of tumor cells and subsequent development of metastasis. Using an experimental metastasis model, we demonstrated that systemic administration of nanomolar concentrations of so-called drag-reducing polymer dramatically impeded extravasation and development of pulmonary metastasis of breast cancer cells in mice. This is the first proof-of-principle study to directly demonstrate physical/rheological, as opposed to chemical, way to prevent cancer cells from extravasation and developing metastasis and, thus, it opens the possibility of a new direction of adjuvant interventional approach in cancer.
机译：转移是癌症死亡的主要原因。癌细胞的外渗是转移的关键步骤。我们报告了一项新的概念验证研究，该研究调查了能够对近壁血管血流进行流变学修饰的无毒可溶血化学药物是否可以减少肿瘤细胞的渗出和随后的转移发展。使用实验性转移模型，我们证明了纳摩尔浓度的所谓减阻聚合物的系统性给药显着阻碍了小鼠乳腺癌细胞的外渗和肺转移的发展。这是第一项直接证明物理/流变方法而非化学方法来预防癌细胞外渗和发展转移的方法的原理研究，因此，它为癌症辅助干预方法的新方向开辟了可能性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号