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首页> 外文期刊>British Biotechnology Journal >Antidiabetic Activity of Basella rubra andits Relationship with the Antioxidant Property
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Antidiabetic Activity of Basella rubra andits Relationship with the Antioxidant Property

机译：巴氏杆菌的抗糖尿病活性及其与抗氧化性能的关系

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Oxidative stress induced by streptozotocin (STZ) has been shown to damage pancreatic beta cell and produce hyperglycemia in rats. In the present study an attempt was made to examine the action of Basella rubra against experimental diabetes as well as the antioxidant potential of the leaf extract. Aqueous extract of Basella rubra (400mg/kg body weight for 30 days) was found to significantly reduce the blood sugar level. The oxidative stress produced by streptozotocin was found to be significantly lowered when compared to control rats. This was evident from a significant decrease in blood sugar level and increased level of liver enzymatic (Super Oxide Dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx)) and non enzymatic antioxidants (vitamin C, E and reduced glutathione). These results indicate that Basella rubra extract effectively reduced the oxidative stress induced by streptozotocin and potential reduction in blood sugar level.
机译：链脲佐菌素（STZ）诱导的氧化应激已显示出会损害大鼠胰腺β细胞并产生高血糖症。在本研究中，我们尝试检查了风葵对实验性糖尿病的作用以及叶提取物的抗氧化能力。发现风叶草提取物（400mg / kg体重，持续30天）可显着降低血糖水平。与对照组相比，链脲佐菌素产生的氧化应激明显降低。从血糖水平显着降低和肝酶水平（超氧化物歧化酶（SOD），过氧化氢酶（CAT），谷胱甘肽过氧化物酶（GPx））和非酶抗氧化剂（维生素C，E和还原型谷胱甘肽）的水平明显提高可以明显看出这一点。这些结果表明，风葵提取物有效地降低了链脲佐菌素诱导的氧化应激和血糖水平的潜在降低。

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