Evaluation of Mutagenic Effects of MonosodiumGlutamate Using Allium cepa and AntimutagenicAction of Origanum majorana L. andRuta chalepensis Medical Plants

Hoda A. Khatab; Nagat S. Elhaddad

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Evaluation of Mutagenic Effects of MonosodiumGlutamate Using Allium cepa and AntimutagenicAction of Origanum majorana L. andRuta chalepensis Medical Plants

机译：洋葱皮对谷氨酸钠诱变效果的评价及牛至和沙鲁芥药用植物的抗诱变作用

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At the present study, Allium cepa root tips were collected during 2,6 and 24 hrs after treated with selected concentrations (1.0,3.0,5.0 and 7.0 g/L) of Mono-Sodium Glutamate (MSG) that used as flavour enhancer in foods. MSG induced mitodepression chromosomal aberrations such as bridges, fragments, disturbance, sticky chromosomes and other morphological abnormalities like enlargement cells. In this study we amid to determine the inhibitory effect of oil extract (1.25 μl/ml) from two medical plant species Origanium majorana L. and Ruta chalepensis on this food additive. Our results demonstrated that these extracts have the potency to suppress MSG by increasing of mitotic index and reduction of the chromosomal aberration and thus could be a promising antimutagenic and antigenotoxic potential.

机译：在本研究中，在用选定浓度（1.0、3.0、5.0和7.0 g / L）的谷氨酸一钠（MSG）处理过的食品中的味觉增强剂处理后的2,6和24小时内，收集了洋葱的洋葱根尖。。 MSG诱导了线粒体抑制染色体畸变，例如桥，片段，干扰，粘稠的染色体以及其他形态异常（如细胞扩增）。在这项研究中，我们试图确定两种药用植物物种Origanium majorana L.和Ruta chalepensis的油提取物（1.25μl/ ml）对这种食品添加剂的抑制作用。我们的结果表明，这些提取物具有通过增加有丝分裂指数和降低染色体畸变来抑制味精的潜能，因此可能具有良好的抗诱变和抗抗原毒性的潜力。

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《British Biotechnology Journal》 |2015年第1期|共11页
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Hoda A. Khatab; Nagat S. Elhaddad;
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中图分类生物工程学（生物技术）;
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Evaluation of Mutagenic Effects of MonosodiumGlutamate Using Allium cepa and AntimutagenicAction of Origanum majorana L. andRuta chalepensis Medical Plants

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