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首页> 外文期刊>British Biotechnology Journal >Hepatic Gene Expression of Insulin like GrowthFactor and Selected Antioxidants in DiabeticRats Treated with Turmeric or Black CuminSeed
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Hepatic Gene Expression of Insulin like GrowthFactor and Selected Antioxidants in DiabeticRats Treated with Turmeric or Black CuminSeed

机译：姜黄或小茴香种子治疗糖尿病大鼠胰岛素样生长因子和所选抗氧化剂的肝基因表达

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The effects of black cumin seed or curcumin on blood glucose level, lipid peroxidation and gene expression of selected antioxidant enzymes and insulin like growth factor-1 (IGF-1) in diabetic rats were studied. Thirty two rats were assigned into four groups (8 rats in each). Rats of first group were non diabetic whereas rats of the second group were rendered diabetic by streptozotocin (STZ). Both groups served as negative and positive controls, respectively. Rats of the third and fourth groups were rendered diabetic and received oral Turmeric (1g/kg b.w.) and Black cumin seed (2g/kg b.w.), respectively for 6 weeks. Diabetic rats showed significant increase of blood glucose, thiobarbituric acid reactive substances (TBARS) and activities of glutathione peroxidase (GPX) and superoxide dismutase (SOD) compared to the control non diabetic group. Gene expression of GPX and SOD was increased significantly in diabetic untreated rats compared to the control non diabetic group. The administration of either black cumin seed or curcumin to diabetic rats normalized significantly their blood sugar level and TBARS values and increased the activities of examined antioxidant enzymes. In addition, both plants treated rats showed significant increase in mRNA expression of IGF-1 and SOD compared to non-diabetic and diabetic untreated rats. Black cumin seed and curcumin was antidiabetic therapy, induced hypoglycemia by up-regulation of IGF-1 gene and ameliorate the diabetes induced oxidative stress via increasing the activities and gene expression of antioxidant enzymes.
机译：研究了黑孜然种子或姜黄素对糖尿病大鼠血糖水平，脂质过氧化作用以及所选抗氧化酶和胰岛素样生长因子-1（IGF-1）基因表达的影响。将三十二只大鼠分为四组（每组八只）。第一组为非糖尿病大鼠，而第二组为链脲佐菌素（STZ）。两组均分别用作阴性和阳性对照。使第三和第四组的大鼠患有糖尿病，并分别接受口服姜黄（1g / kg b.w.）和黑孜然籽（2g / kg b.w.）6周。与非糖尿病对照组相比，糖尿病大鼠显示血糖，硫代巴比妥酸反应性物质（TBARS）以及谷胱甘肽过氧化物酶（GPX）和超氧化物歧化酶（SOD）的活性显着增加。与非糖尿病对照组相比，未治疗的糖尿病大鼠中GPX和SOD的基因表达显着增加。对糖尿病大鼠施用黑孜然种子或姜黄素可显着使其血糖水平和TBARS值正常化，并增加了检查的抗氧化酶的活性。另外，与未糖尿病和糖尿病未治疗的大鼠相比，两种植物治疗的大鼠均显示IGF-1和SOD的mRNA表达显着增加。黑孜然籽和姜黄素具有抗糖尿病作用，它通过上调IGF-1基因来诱导低血糖症，并通过增加抗氧化酶的活性和基因表达来减轻糖尿病引起的氧化应激。

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