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首页> 外文期刊>BMC Microbiology >Pherotypes are driving genetic differentiation within Streptococcus pneumoniae
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Pherotypes are driving genetic differentiation within Streptococcus pneumoniae

机译：基因型正在驱动肺炎链球菌内的遗传分化

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Background The boundaries of bacterial species and the mechanisms underlying bacterial speciation are matters of intense debate. Theoretical studies have shown that recombination acts as a strong cohesive force preventing divergence in bacterial populations. Streptococcus pneumoniae populations have the telltale signs of high recombination with competence implicated as the major driving force behind gene exchange. Competence in S. pneumoniae is triggered by a quorum-sensing mechanism controlled by the competence-stimulating peptide pheromone. Results We studied the distribution of the two major pherotypes in the pneumococcal population and their association with serotype, antimicrobial resistance and genetic lineage. Using multilocus sequence data we evaluated pherotype influence on the dynamics of horizontal gene transfer. We show that pherotype is a clonal property of pneumococci. Standard population genetic analysis and multilocus infinite allele model simulations support the hypothesis that two genetically differentiated populations are defined by the major pherotypes. Conclusion Severe limitations to gene flow can therefore occur in bacterial species in the absence of geographical barriers and within highly recombinogenic populations. This departure from panmixia can have important consequences for our understanding of the response of pneumococci to human imposed selective pressures such as vaccination and antibiotic use.
机译：背景技术细菌种类的边界和潜在的细菌物种形成机制引起了激烈的争论。理论研究表明，重组具有很强的内聚力，可防止细菌种群发生分化。肺炎链球菌种群具有高重组的明显迹象，其能力被认为是基因交换背后的主要驱动力。肺炎链球菌的能力是由能刺激能力的肽信息素控制的群体感应机制触发的。结果我们研究了肺炎球菌人群中两种主要的基因型分布及其与血清型，抗菌素耐药性和遗传谱系的关系。使用多基因座序列数据，我们评估了基因型对水平基因转移动力学的影响。我们表明，分型是肺炎球菌的克隆特性。标准种群遗传分析和多基因座无限等位基因模型模拟支持以下假设：两个基因分化的种群由主要表型定义。结论因此，在没有地理障碍的情况下，在高度重组的种群内，细菌物种中可能会出现严重的基因流限制。对我们的理解肺炎球菌对人类施加的选择性压力（如疫苗接种和抗生素使用）的反应可能会产生重大后果。

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