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首页> 外文期刊>British Journal of Pharmaceutical Research >Anti-inflammatory and Antinociceptive Effects of the Aqueous Extract of the Bark of Chrysobalanus icaco Linnaeus
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Anti-inflammatory and Antinociceptive Effects of the Aqueous Extract of the Bark of Chrysobalanus icaco Linnaeus

机译：金银花树皮水提液的抗炎和镇痛作用

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Aims: This paper describes the anti-in???ammatory and antinociceptive effects of the aqueous extract of Chrysobalanus icaco. Study Design: Study the anti-inflammatory and antinociceptive activity of the aqueous extract of C. icaco using in vivo models. Place and Duration of Study: Department of Antibiotics and Department of Pharmaceutical Science, Federal University of Pernambuco, Recife, Pernambuco, Brazil, between March 2010 and March 2012. Methodology: The anti-inflammatory activity was evaluated by carrageenan/dextran-induced paw edema, vascular permeability induced by acetic acid and subcutaneous air pouch models, with measurements of cell migration, nitric oxide and cytokines TNF-α and IL-6. Acetic acid-induced abdominal writhing, formalin and hot plate tests were performed to investigate the antinociceptive effects. Results: The aqueous extract of C. icaco (100, 200 and 400 mg/kg) reduced dextran/carrageenan-induced rat paw edema, the vascular permeability, cell migration, and nitric oxide concentration. However, it did not affect the levels of TNF-α and IL-6 produced in the pouch. The aqueous extract also demonstrated antinociceptive activity by acetic acid-induced abdominal writhing and formalin test, and was able to prolong the reaction time in the hot plate model in the first hour with activity similar to morphine (2.5 mg/kg, s.c.). There was no acute toxicity in mice after oral administration of the aqueous extract at doses of 2 g/kg. Conclusion: Our results indicate that the aqueous extract of C. icaco demonstrated anti-in???ammatory activity through the reduction of vascular permeability, inhibition of cellular migration and nitric oxide production and that the antinociceptive activity seems to be mediated by central mechanisms.
机译：目的：本文描述了金银花水提取物的抗炎和镇痛作用。研究设计：使用体内模型研究C. icaco水提取物的抗炎和镇痛活性。研究的地点和持续时间：2010年3月至2012年3月之间，巴西伯南布哥州累西腓伯南布哥联邦大学抗生素系和药物科学系。方法：通过角叉菜胶/葡聚糖诱导的足爪水肿评估抗炎活性乙酸和皮下气囊模型诱发的血管通透性，并测量细胞迁移，一氧化氮和细胞因子TNF-α和IL-6。进行了乙酸诱导的腹部扭伤，福尔马林和热板试验，以研究其镇痛作用。结果：C. icaco的水提取物（100、200和400 mg / kg）减少了葡聚糖/角叉菜胶诱导的大鼠爪水肿，血管通透性，细胞迁移和一氧化氮浓度。但是，它不会影响袋中产生的TNF-α和IL-6的水平。该水提取物还通过乙酸引起的腹部扭体和福尔马林试验显示出抗伤害感受活性，并且能够在热板模型中在第一小时内延长反应时间，其活性类似于吗啡（2.5 mg / kg，s.c.）。口服给予2 g / kg的水提取物后，小鼠没有急性毒性。结论：我们的结果表明，C。icaco的水提取物通过降低血管通透性，抑制细胞迁移和产生一氧化氮而表现出抗炎活性，并且抗伤害感受活性似乎是由中枢机制介导的。

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