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首页> 外文期刊>BMC Neuroscience >Modulating spontaneous brain activity using repetitive transcranial magnetic stimulation
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Modulating spontaneous brain activity using repetitive transcranial magnetic stimulation

机译：使用重复经颅磁刺激调节自发性大脑活动

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Background When no specific stimulus or task is presented, spontaneous fluctuations in brain activity occur. Brain regions showing such coherent fluctuations are thought to form organized networks known as 'resting-state' networks, a main representation of which is the default mode network. Spontaneous brain activity shows abnormalities in several neurological and psychiatric diseases that may reflect disturbances of ongoing thought processes. Information about the degree to which such spontaneous brain activity can be modulated may prove helpful in the development of treatment options. We investigated the effect of offline low-frequency rTMS on spontaneous neural activity, as measured with fMRI, using a sequential independent-component-analysis and regression approach to investigate local changes within the default mode network. Results We show that rTMS applied over the left dorsolateral prefrontal cortex results in distal changes of neural activity, relative to the site of stimulation, and that these changes depend on the patterns of brain network activity during 'resting-state'. Conclusions Whereas the proximal changes may reflect the off-line effect of direct stimulation of neural elements, the distal changes likely reflect modulation of functional connectivity.
机译：背景当没有特定的刺激或任务出现时，大脑活动会发生自发性波动。表现出这种连贯波动的大脑区域被认为形成了被称为“静止状态”网络的组织化网络，其主要代表是默认模式网络。自发性大脑活动显示出几种神经和精神疾病的异常，这可能反映出正在进行的思维过程受到干扰。关于可以调节这种自发性大脑活动程度的信息可能有助于开发治疗选择。我们研究了离线低频rTMS对自发性神经活动的影响（如使用fMRI进行测量），使用顺序独立成分分析和回归方法研究默认模式网络内的局部变化。结果我们显示，相对于刺激部位，rTMS应用于左侧背外侧前额叶皮层会导致神经活动的远端变化，并且这些变化取决于“静止状态”期间脑网络活动的模式。结论尽管近端变化可能反映了直接刺激神经元的离线效应，但远端变化可能反映了功能连接的调节。

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