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首页> 外文期刊>BMC Neuroscience >Maternal separation with early weaning: a novel mouse model of early life neglect
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Maternal separation with early weaning: a novel mouse model of early life neglect

机译：母婴分离和早期断奶：一种忽略早期生命的新型小鼠模型

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Background Childhood adversity is associated with increased risk for mood, anxiety, impulse control, and substance disorders. Although genetic and environmental factors contribute to the development of such disorders, the neurobiological mechanisms involved are poorly understood. A reliable mouse model of early life adversity leading to lasting behavioral changes would facilitate progress in elucidating the molecular mechanisms underlying these adverse effects. Maternal separation is a commonly used model of early life neglect, but has led to inconsistent results in the mouse. Results In an effort to develop a mouse model of early life neglect with long-lasting behavioral effects in C57BL/6 mice, we designed a new maternal separation paradigm that we call Maternal Separation with Early Weaning (MSEW). We tested the effects of MSEW on C57BL/6 mice as well as the genetically distinct DBA/2 strain and found significant MSEW effects on several behavioral tasks (i.e., the open field, elevated plus maze, and forced swim test) when assessed more than two months following the MSEW procedure. Our findings are consistent with MSEW causing effects within multiple behavioral domains in both strains, and suggest increased anxiety, hyperactivity, and behavioral despair in the MSEW offspring. Analysis of pup weights and metabolic parameters showed no evidence for malnutrition in the MSEW pups. Additionally, strain differences in many of the behavioral tests suggest a role for genetic factors in the response to early life neglect. Conclusions These results suggest that MSEW may serve as a useful model to examine the complex behavioral abnormalities often apparent in individuals with histories of early life neglect, and may lead to greater understanding of these later life outcomes and offer insight into novel therapeutic strategies.
机译：背景儿童的逆境与情绪，焦虑，冲动控制和物质紊乱的风险增加有关。尽管遗传和环境因素促成此类疾病的发展，但所涉及的神经生物学机制知之甚少。导致持久行为改变的可靠的早期逆境小鼠模型将有助于阐明这些不良作用的分子机制。母体分离是早期忽视生命的一种常用模型，但导致小鼠的结果不一致。结果为了开发对C57BL / 6小鼠具有长期行为影响而忽略的早期生命的小鼠模型，我们设计了一种新的母体分离范例，我们将其称为“早期断奶母体分离”（MSEW）。我们测试了MSEW对C57BL / 6小鼠以及遗传学上不同的DBA / 2品系的影响，发现当评估为大于MSEW程序后两个月。我们的发现与MSEW在这两个菌株的多个行为域内引起的效应是一致的，并表明MSEW后代中焦虑，过度活跃和行为绝望的增加。对幼崽体重和代谢参数的分析表明，没有证据表明MSEW幼崽营养不良。此外，许多行为测试中的应变差异表明遗传因素在对早期生活中忽视的反应中起着作用。结论这些结果表明，MSEW可以用作检查复杂的行为异常的有用模型，这些异常行为通常在有早期生命史的个人中经常出现，并且可以导致对这些晚期生命结局的更多了解，并为新的治疗策略提供见识。

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