...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BMC Neuroscience >Altered neurological function in mice immunized with early endosome antigen 1
【24h】

Altered neurological function in mice immunized with early endosome antigen 1

机译：早期内体抗原1免疫小鼠的神经功能改变

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Autoantibodies directed against the 160 kDa endosome protein early endosome antigen 1 (EEA1) are seen in patients with neurological diseases. To determine if antibodies to EEA1 have a neuropathological effect, mice from three major histocompatability haplotype backgrounds (H2q, H2b and H2d) were immunized with EEA1 (amino acids 82–1411) that was previously shown to contain the target EEA1 epitopes. The mice were then subjected to five neuro-behavioural tests: grid walking, forelimb strength, open field, reaching and rotarod. Results The immunized SWR/J mice with sustained anti-EEA1 antibodies had significantly reduced forelimb strength than the control non-immune mice of the same strain, and BALB/CJ immune mice demonstrated significantly more forelimb errors on the grid walk test than the control group. Conclusions Antibodies to recombinant EEA1 in mice may mediate neurological deficits that are consistent with clinical features of some humans that spontaneously develop anti-EEA1 autoantibodies.
机译：背景在患有神经系统疾病的患者中发现了针对160 kDa内体蛋白早期内体抗原1（EEA1）的自身抗体。为了确定抗EEA1的抗体是否具有神经病理学作用，分别使用了来自三种主要组织相容性单倍型背景（H2 q ，H2 b 和H2 d ）的小鼠用先前显示包含靶EEA1表位的EEA1（氨基酸82-1411）进行免疫。然后对小鼠进行五项神经行为测试：走网，前肢力量，空旷，伸手和旋转脚。结果带有抗EEA1抗体的SWR / J免疫小鼠的前肢力量显着低于相同品系的对照非免疫小鼠，而BALB / CJ免疫小鼠的步走误差比对照组明显更高。结论小鼠重组EEA1抗体可能介导神经功能缺损，这与某些自发产生抗EEA1自身抗体的人的临床特征一致。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号