• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BMC Neuroscience >Response of regional brain glutamate transaminases of rat to aluminum in protein malnutrition
【24h】

Response of regional brain glutamate transaminases of rat to aluminum in protein malnutrition

机译：蛋白质营养不良对大鼠局部谷氨酸谷氨酸转氨酶对铝的反应

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background The mechanism of aluminum-induced neurotoxicity is not clear. The involvement of glutamate in the aluminium-induced neurocomplications has been suggested. Brain glutamate levels also found to be altered in protein malnutrition. Alterations in glutamate levels as well as glutamate-α-decarboxylase in different regions of rat brain has been reported in response to aluminum exposure. Thus the study of glutamate metabolising enzymes in different brain regions of rats maintained on either normal or restricted protein diet may be of importance for understanding the neurotoxicity properties of aluminium. Results Dietary protein restrictions does not have an significant impact on regional aluminum content of the brain. The interaction of aluminum intoxication and protein restriction is significant in the thalamic area and the midbrain-hippocampal region in cases of glutamate oxaloacetate transaminase. In the case of gluatmate pyruvate transaminase, this interaction is significant only in thalamic area. Conclusion The metabolism of amino acids, as indicated by activities of specific transaminases, of brain is altered in response to aluminum exposure. These alterations are region specific and are dependent on dietary protein intake or manipulation of the brain amino acid homeostasis.
机译：背景铝诱导的神经毒性的机制尚不清楚。已提出谷氨酸参与铝诱导的神经并发症。也发现脑谷氨酸水平在蛋白质营养不良中有所改变。据报道，由于铝暴露，大鼠大脑不同区域的谷氨酸水平以及谷氨酸-α-脱羧酶发生了变化。因此，研究维持正常或受限蛋白质饮食的大鼠不同大脑区域的谷氨酸代谢酶对于理解铝的神经毒性特性可能具有重要意义。结果饮食中的蛋白质限制对大脑区域铝含量没有显着影响。在谷氨酸草酰乙酸转氨酶的情况下，铝中毒和蛋白质限制的相互作用在丘脑区域和中脑-海马区显着。在谷氨酸丙酮酸转氨酶的情况下，这种相互作用仅在丘脑区域显着。结论铝的反应改变了特定转氨酶活性所表明的氨基酸的代谢。这些改变是区域特异性的，并取决于饮食蛋白质的摄入或脑氨基酸稳态的操纵。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号