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首页> 外文期刊>BMC Neuroscience >Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following spinal cord ischemia in rabbits
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Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following spinal cord ischemia in rabbits

机译：川tra嗪对兔脊髓缺血后的抗凋亡和神经保护作用

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Background Tetramethylpyrazine (TMP) is one of the most important active ingredients of a Chinese herb Ligusticum wallichii Franchat, which is widely used in many ischemia disorders treatments. However, the exact mechanism by which TMP protects the spinal cord ischemia/reperfusion (I/R) injury is still unknown. For this purpose, rabbits were randomly divided into sham group, control group and TMP group. After the evaluation of neurologic function, the spinal cords were immediately removed for biochemical and histopathological analysis. Apoptosis was measured quantitatively by the terminal transferase UTP nick end-labeling (TUNEL) method and confirmed by electron microscopic examination, the expression of Bax and Bcl-2 was immunohistochemically evaluated and quantified by Western blot analysis. Results Neurologic outcomes in the TMP-group were significantly better than those in the control group (P Conclusion These findings suggest that TMP has protective effects against spinal cord I/R injury by reducing apoptosis through regulating Bcl-2 and Bax expression.
机译：背景技术川methyl嗪（TMP）是中草药女贞草的最重要的活性成分之一，广泛用于许多缺血性疾病的治疗中。但是，TMP保护脊髓缺血/再灌注（I / R）损伤的确切机制仍是未知的。为此，将兔随机分为假手术组，对照组和TMP组。在评估神经功能后，立即取出脊髓进行生化和组织病理学分析。通过末端转移酶UTP缺口末端标记法（TUNEL）定量测量细胞凋亡，并通过电子显微镜检查确认，免疫组织化学评估Bax和Bcl-2的表达，并通过蛋白质印迹分析定量。结果TMP组的神经学结果明显优于对照组（P结论）。这些发现表明TMP通过调节Bcl-2和Bax表达减少凋亡，从而对脊髓I / R损伤具有保护作用。

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