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首页> 外文期刊>BMC Neuroscience >Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study
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Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study

机译：经颅聚焦超声对7T fMRI对人原发性运动皮层的影响：一项初步研究

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Transcranial focused ultrasound (tFUS) is a new non-invasive neuromodulation technique that uses mechanical energy to modulate neuronal excitability with high spatial precision. tFUS has been shown to be capable of modulating EEG brain activity in humans that is spatially restricted, and here, we use 7T MRI to extend these findings. We test the effect of tFUS on 7T BOLD fMRI signals from individual finger representations in the human primary motor cortex (M1) and connected cortical motor regions. Participants (N?=?5) performed a cued finger tapping task in a 7T MRI scanner with their thumb, index, and middle fingers to produce a BOLD signal for individual M1 finger representations during either tFUS or sham neuromodulation to the thumb representation. Results demonstrated a statistically significant increase in activation volume of the M1 thumb representation for the tFUS condition as compared to sham. No differences in percent BOLD changes were found. This effect was spatially confined as the index and middle finger M1 finger representations did not show similar significant changes in either percent change or activation volume. No effects were seen during tFUS to M1 in the supplementary motor area or the dorsal premotor cortex. Single element tFUS can be paired with high field MRI that does not induce significant artifact. tFUS increases activation volumes of the targeted finger representation that is spatially restricted within M1 but does not extend to functionally connected motor regions.
机译：经颅聚焦超声（tFUS）是一种新的非侵入性神经调节技术，它利用机械能以高空间精度调节神经元兴奋性。已经证明tFUS能够调节受空间限制的人类脑电活动，在这里，我们使用7T MRI扩展了这些发现。我们测试了tFUS对人类主要运动皮层（M1）和相连的皮质运动区中各个手指表示的7T BOLD fMRI信号的影响。参与者（N≥5）在7T MRI扫描仪中用拇指，食指和中指执行了提示性的手指轻敲任务，以在tFUS或对拇指表示进行伪神经调制期间产生单个M1手指表示的BOLD信号。结果显示，与假手术相比，tFUS条件下M1拇指表示的激活量有统计学意义的增加。未发现BOLD变化百分比的差异。这种影响在空间上受到限制，因为食指和中指M1手指表示在百分比变化或激活音量上均未显示出相似的显着变化。在tFUS至M1期间，在辅助运动区或背运动前皮层中未观察到任何影响。可以将单元素tFUS与不会引起明显伪像的高场MRI配对。 tFUS增加了目标手指表示的激活体积，该激活体积在空间上限制在M1内，但不会扩展到功能连接的运动区域。

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