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首页> 外文期刊>BMC Pediatrics >High DMBT1 concentrations in breast milk correlate with increased risk of infection in preterm and term neonates
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High DMBT1 concentrations in breast milk correlate with increased risk of infection in preterm and term neonates

机译：母乳中的高DMBT1浓度与早产和足月新生儿的感染风险增加相关

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Background Human milk contains immune molecules involved in the protection of newborns against infections. We analyzed the concentration of Deleted in Malignant Brain Tumors 1 (DMBT1), a protein with functions in innate immunity, in breast milk. Methods DMBT1 was detected in breast milk by Western blotting and its concentration was quantified by ELISA in 95 breast milk samples collected from mothers of preterm and term neonates during the first four weeks after delivery. Possible effects of maternal or neonatal parameters were analyzed by different statistical tests. Results The mean DMBT1 concentration (± standard error of the mean) in the tested milk samples was 2.48?±?0.26?μg/mL (range: 0.112?μg/mL to 17.984?μg/mL) and represented 0.0087% of the total protein content. The comparison between the newborns with infection and the newborns without infection revealed significantly higher DMBT1 concentrations in breast milk in the group with infection (6.72?±?2.53?μg/mL versus 2.20?±?0.35?μg/mL (P?=?0.031)). Neither maternal nor neonatal parameters showed a correlation with the milk DMBT1 levels. Conclusions DMBT1 is a component of breast milk after birth and is up-regulated in the breast milk from mothers with newborns suffering from neonatal infection. Thus, breast milk DMBT1 may be part of the innate immunity similar to secretory IgA.
机译：背景技术人乳包含免疫分子，其参与保护新生儿免受感染。我们分析了母乳中的恶性脑肿瘤1（DMBT1）（一种具有先天免疫功能的蛋白质）的浓度。方法在分娩后的头四个星期内，从早产和足月新生儿的母亲那里采集的95份母乳样品中，通过Western印迹法在母乳中检测到DMBT1，并通过ELISA定量检测其浓度。孕产妇或新生儿参数的可能影响通过不同的统计检验进行了分析。结果牛奶样品中的DMBT1平均浓度为2.48±±0.26μg/ mL（范围：0.112μg/ mL至17.984μg/ mL），占总量的0.0087％。蛋白质含量。比较感染的新生儿和未感染的新生儿，发现感染组母乳中的DMBT1浓度显着较高（6.72±2.53？μg/ mL，而2.20±0.35μg/ mL（P =？ 0.031））。孕产妇和新生儿参数均未显示与牛奶DMBT1水平相关。结论DMBT1是出生后母乳中的一个成分，并且在患有新生儿感染的新生儿的母亲的母乳中被上调。因此，母乳DMBT1可能是先天免疫力的一部分，类似于分泌型IgA。

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