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首页> 外文期刊>BMC Pediatrics >Prevalence of congenital defects including selected neural tube defects in Nepal: results from a health survey
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Prevalence of congenital defects including selected neural tube defects in Nepal: results from a health survey

机译：尼泊尔包括先天性神经管缺陷在内的先天性缺陷患病率：健康调查结果

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Background In resource-limited nations like Nepal, congenital defects, including neural tube defects (NTDs), have great public health impact. NTDs and a few other congenital defects can be prevented by micronutrient supplementation. Without proper research regarding such defects, it is difficult to assess the damage made to health and productivity. This study aims to investigate different congenital defects among children in Nepal. Methods Household surveys and health camps were conducted from 2011 to 2012. Physical examination of women of reproductive age (15 to 49?years) was done in selected Village Development Committees of nine districts in three ecological regions of Nepal. Congenital defects, including NTDs, were examined in children (age 0 to 5?years) who were alive at the time of the survey. Data entry and analysis was performed by using SPSS version 11.5. Results 21,111 women were interviewed and 27,201 children born to them were assessed. The prevalence of congenital defects was 52.0 (95?% CI: 44.0–61.0) per 10,000 children. The prevalence of selected NTDs was 4.0 (95?% CI: 2.0–7.0) per 10,000 children. Among the neural tube defects, encephalocele, myelomeningocele and dermal sinus were the major ones, having almost the same prevalence in the Hill and Terai regions. The majority of children with genital abnormalities (17.0 per 10,000 children; 95?% CI: 10.0–28.0) and limb deformities (14.0 per 10,000 children; 95?% CI: 8.0–24.0) were found in the Terai. The rate of congenital birth defects was higher in the regions where women were in poor health. Conclusion There is high prevalence of congenital defects in Nepal. Since such defects add a burden to families and society, it is imperative that health policies addressing programs like supplementation, fortification and dietary diversification be implemented.
机译：背景技术在像尼泊尔这样资源有限的国家中，先天性缺陷，包括神经管缺陷（NTD），对公共健康产生重大影响。补充微量营养素可以预防NTD和其他一些先天性缺陷。如果不对此类缺陷进行适当的研究，则很难评估对健康和生产力造成的损害。这项研究旨在调查尼泊尔儿童中不同的先天性缺陷。方法2011年至2012年进行了家庭调查和保健营。在尼泊尔三个生态区的9个地区的选定村庄发展委员会中，对15岁至49岁的育龄妇女进行了身体检查。在调查时，对活着的儿童（0至5岁）中的先天性缺陷（包括NTD）进行了检查。使用SPSS 11.5版进行数据输入和分析。结果采访了21,111名女性，并对其中所生的27,201名儿童进行了评估。每10,000名儿童中，先天性缺陷的患病率为52.0（95％CI：44.0-61.0）。每10,000名儿童中，选择的NTD患病率为4.0（95％CI：2.0–7.0）。在神经管缺陷中，脑膨出，脊髓膜膨出和真皮窦是主要的缺陷，在Hill和Terai地区的患病率几乎相同。在特赖州，发现大多数生殖器异常儿童（每10,000名儿童17.0; CI为95？％10.0–28.0）和肢体畸形（每10,000名儿童为14.0; 95％CI：8.0–24.0）。妇女健康状况欠佳的地区，先天性先天缺陷的发生率更高。结论尼泊尔的先天性缺陷患病率很高。由于此类缺陷给家庭和社会增加了负担，因此必须执行针对诸如补充，强化和饮食多样化等计划的卫生政策。

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