...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BMC Pediatrics >Long-term effects of an inpatient weight-loss program in obese children and the role of genetic predisposition-rationale and design of the LOGIC-trial
【24h】

Long-term effects of an inpatient weight-loss program in obese children and the role of genetic predisposition-rationale and design of the LOGIC-trial

机译：住院减肥计划对肥胖儿童的长期影响以及遗传易感性的作用和LOGIC试验的设计

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background The prevalence of childhood obesity has increased worldwide, which is a serious concern as obesity is associated with many negative immediate and long-term health consequences. Therefore, the treatment of overweight and obesity in children and adolescents is strongly recommended. Inpatient weight-loss programs have shown to be effective particularly regarding short-term weight-loss, whilst little is known both on the long-term effects of this treatment and the determinants of successful weight-loss and subsequent weight maintenance. The purpose of this study is to evaluate the short, middle and long-term effects of an inpatient weight-loss program for children and adolescents and to investigate the likely determinants of weight changes, whereby the primary focus lies on the potential role of differences in polymorphisms of adiposity-relevant genes. Methods/Design The study involves overweight and obese children and adolescents aged 6 to 19 years, who participate in an inpatient weight-loss program for 4 to 6 weeks. It started in 2006 and it is planned to include 1,500 participants by 2013. The intervention focuses on diet, physical activity and behavior therapy. Measurements are taken at the start and the end of the intervention and comprise blood analyses (DNA, lipid and glucose metabolism, adipokines and inflammatory markers), anthropometry (body weight, height and waist circumference), blood pressure, pubertal stage, and exercise capacity. Physical activity, dietary habits, quality of life, and family background are assessed by questionnaires. Follow-up assessments are performed 6 months, 1, 2, 5 and 10 years after the intervention: Children will complete the same questionnaires at all time points and visit their general practitioner for examination of anthropometric parameters, blood pressure and assessment of pubertal stage. At the 5 and 10 year follow-ups, blood parameters and exercise capacity will be additionally measured. Discussion Apart from illustrating the short, middle and long-term effects of an inpatient weight-loss program, this study will contribute to a better understanding of inter-individual differences in the regulation of body weight, taking into account the role of genetic predisposition and lifestyle factors. Trial Registration NCT01067157 .
机译：背景技术全世界儿童肥胖症的患病率上升，这是一个严重的问题，因为肥胖症与许多负面的即时和长期健康后果相关。因此，强烈建议对儿童和青少年的超重和肥胖症进行治疗。住院减肥计划已显示出特别有效的短期减肥效果，而对这种治疗的长期效果以及成功减肥和随后维持体重的决定因素知之甚少。这项研究的目的是评估住院减肥计划对儿童和青少年的短期，中期和长期影响，并调查体重变化的可能决定因素，其中主要重点在于差异的潜在作用。肥胖相关基因的多态性。方法/设计该研究涉及6至19岁的超重和肥胖儿童及青少年，他们参加了4至6周的住院减肥计划。它始于2006年，预计到2013年将有1,500名参与者参加。干预措施集中在饮食，身体活动和行为疗法上。在干预的开始和结束时进行测量，包括血液分析（DNA，脂质和葡萄糖代谢，脂肪因子和炎性标志物），人体测量学（体重，身高和腰围），血压，青春期和运动能力。身体活动，饮食习惯，生活质量和家庭背景通过问卷进行评估。干预后6个月，1、2、5和10年进行随访评估：孩子们将在所有时间点填写相同的问卷，并拜访全科医生以进行人体测量学参数，血压和青春期评估。在5年和10年的随访中，将另外测量血液参数和运动能力。讨论除了说明住院减重计划的短期，中期和长期影响外，该研究还将考虑遗传易感性和生活方式因素。试用注册NCT01067157。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号