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首页> 外文期刊>British Journal of Medicine and Medical Research >Dynamic Anatomy of Aortic Root and Its Potential Role in TAVR Prostheses Further Development and Modification
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Dynamic Anatomy of Aortic Root and Its Potential Role in TAVR Prostheses Further Development and Modification

机译：主动脉根的动态解剖及其在TAVR修复体中的潜在作用

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Aortic stenosis (AS) is the most common valvular disorder. Surgical aortic valve replacement is the definitive therapy for patients with severe AS. In the last years transcatheter aortic valve replacement (TAVR) has been developed as an alternative to surgical aortic valve replacement with promising results. Despite being less invasive than open-chest aortic valve replacement, good outcome and effectiveness of TAVR procedure, it remains associated with the potential for serious complications and short-time durability. Today there are two TAVR prostheses that have CE marks and FDA approved: Edwards Valves and CoreValve. Besides there are many other newly developed TAVR prostheses on the stage of clinical trials. However, no one of them had been developed on the base of data for dynamic anatomy of human aortic root because of the lack of appropriate imaging modality. Today, different two-dimensional (2D) and three-dimensional (3D) imaging techniques are used for aortic root examination. But no one of them has been accepted as a “gold standard” imaging modality for assessment of dynamic anatomy of aortic root. The existing imaging modalities such as transthoracic echocardiography, transesophageal echocardiography, angiography, CT and MRI scans provide tangential cut plane view which did not reflect the real sizes of the annulus and other aortic root rings and structures. Obtained with these modalities images did not reflect the changes of the size and shapes of the anatomic structures of aortic root during the different phase of cardiac cycles either. Today there are strict needs for imaging modality which could assist in assessment of dynamic aortic root to push the TAVR prosthesis design and modification on new level.
机译：主动脉瓣狭窄（AS）是最常见的瓣膜疾病。外科主动脉瓣置换术是严重AS患者的最终治疗方法。近年来，经导管主动脉瓣置换术（TAVR）已被开发为外科主动脉瓣置换术的替代方法，并取得了可喜的成果。尽管比开胸主动脉瓣置换术创伤小，TAVR手术效果好，效果好，但它仍然具有严重并发症和短期持久性的潜力。如今，有两种带有CE标志并获得FDA批准的TAVR假体：Edwards Valves和CoreValve。此外，在临床试验阶段还有许多其他新开发的TAVR假体。然而，由于缺乏适当的成像方式，因此没有人依据人类主动脉根的动态解剖学开发任何一种方法。如今，将不同的二维（2D）和三维（3D）成像技术用于主动脉根检查。但是，没有人被认为是评估主动脉根动态解剖结构的“金标准”成像方式。现有的影像学检查方法如经胸超声心动图，经食管超声心动图，血管造影，CT和MRI扫描可提供切向切面视图，该切面图不能反映瓣环和其他主动脉根环和结构的真实尺寸。用这些方式获得的图像也不能反映在心动周期的不同阶段中主动脉根的解剖结构的大小和形状的变化。如今，对成像方式的严格需求可以帮助评估动态主动脉根，从而将TAVR假体的设计和修改推向新的高度。

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