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首页> 外文期刊>Bulletin of the Medical Library Association. >Medical literature as a potential source of new knowledge.
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Medical literature as a potential source of new knowledge.

机译：医学文献可作为新知识的潜在来源。

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Specialized biomedical literatures have been found that are implicitly linked by arguments that they respectively contain, but which nonetheless do not cite or refer to each other. The combined arguments lead to new inferences and conclusions that cannot be drawn from the separate literatures. One such analysis identified one set of articles showing that dietary fish oils lead to certain blood and vascular changes, and a second set containing evidence that similar changes might benefit patients with Raynaud's syndrome. Yet these two literatures had no articles in common and had never before been cited together; neither literature mentioned the other or suggested that dietary fish oil might benefit Raynaud patients. Two years after publication of that analysis, the first clinical trial demonstrating such a beneficial effect was reported independently by others. A second example of literature synthesis, based on eleven indirect connections, led to an inference that magnesium deficiency might be a causal factor in migraine headache. A third example calls attention to implicit connections between arginine intake and blood levels of somatomedins, a potentially fruitful but neglected area of research with implications for the decline with age of thymic function and protein synthesis. A model and an online search strategy to aid in identifying other logically related noninteractive literatures is described. Such structures are probably not rare and may provide the foundation for a literature-based approach to scientific discovery.
机译：已经找到了专门的生物医学文献，这些文献被它们各自包含的论点隐含地联系在一起，但是它们并没有相互引用或相互引用。合并的论点导致无法从单独的文献中得出新的推论和结论。一项这样的分析确定了一组文章，这些文章表明饮食中的鱼油会导致某些血液和血管的变化，而第二组则包含类似变化可能使雷诺氏综合症患者受益的证据。然而，这两种文献没有共同之处，也从未被一起引用过。既没有文献提到彼此，也没有建议饮食中食用鱼油可能会使Raynaud患者受益。该分析发表两年后，其他人独立报道了第一个证明这种疗效的临床试验。基于11个间接联系的文献合成的第二个例子得出的结论是，镁缺乏可能是偏头痛的病因。第三个例子提醒人们注意精氨酸摄入量与血豆素的血液含量之间的隐式联系，这可能是富有成果但被忽视的研究领域，对胸腺功能和蛋白质合成的年龄下降具有影响。描述了一种有助于识别其他逻辑相关的非交互式文献的模型和在线搜索策略。这样的结构可能并不罕见，并且可以为基于文献的科学发现方法提供基础。

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