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Polymorphisms of EpCAM gene and prognosis for non‐small‐cell lung cancer in Han Chinese

机译：EpCAM基因多态性与非小细胞肺癌的预后

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AbstractThe epithelial cell adhesion molecule (EpCAM) is overexpressed in a wide variety of human cancers and is associated with patient prognosis, including those with lung cancer. However, the association of single nucleotide polymorphisms (SNPs) in the EpCAM gene with the prognosis for non-small-cell lung cancer (NSCLC) patients has never been investigated. We evaluated the association between two SNPs, rs1126497 and rs1421, in the EpCAM gene and clinical outcomes in a Chinese cohort of 506 NSCLC patients. The SNPs were genotyped using the Sequenom iPLEX genotyping system. Multivariate Cox proportional hazards model and Kaplan–Meier curves were used to assess the association of EpCAM gene genotypes with the prognosis of NSCLC. We found that the non-synonymous SNP rs1126497 was significantly associated with survival. Compared with the CC genotype, the CT+TT genotype was a risk factor for both death (hazard ratio, 1.40; 95% confidence interval [CI], 1.02–1.94; P = 0.040) and recurrence (hazard ratio, 1.34; 95% CI, 1.02–1.77; P = 0.039). However, the SNP rs1421 did not show any significant effect on patient prognosis. Instead, the AG+GG genotype in rs1421 was significantly associated with early T stages (T1/T2) when compared with the AA genotype (odds ratio for late stage = 0.65; 95% CI, 0.44–0.96, P = 0.029). Further stratified analysis showed notable modulating effects of clinical characteristics on the associations between variant genotypes of rs1126497 and NSCLC outcomes. In conclusion, our study indicated that the non-synonymous SNP rs1126497 may be a potential prognostic marker for NSCLC patients.
机译：摘要上皮细胞粘附分子（EpCAM）在多种人类癌症中过表达，并且与患者的预后有关，包括肺癌。但是，从未研究过EpCAM基因中的单核苷酸多态性（SNPs）与非小细胞肺癌（NSCLC）患者预后的关系。我们评估了中国人群506名NSCLC患者中EpCAM基因中的两个SNP rs1126497和rs1421之间的关联以及临床结局。使用Sequenom iPLEX基因分型系统对SNP进行基因分型。多元Cox比例风险模型和Kaplan–Meier曲线用于评估EpCAM基因型与NSCLC预后的关系。我们发现非同义SNP rs1126497与生存率显着相关。与CC基因型相比，CT + TT基因型既是死亡（危险比，1.40; 95％置信区间[CI]，1.02-1.94; P = 0.040）也是复发（危险比，1.34; 95％）的危险因素CI，1.02-1.77; P = 0.039）。但是，SNP rs1421对患者的预后未显示任何显着影响。相反，与AA基因型相比，rs1421中的AG + GG基因型与T早期阶段（T1 / T2）显着相关（晚期的奇数比= 0.65; 95％CI，0.44-0.96，P = 0.029）。进一步的分层分析显示，临床特征对rs1126497变异基因型与NSCLC结果之间的关联具有显着的调节作用。总之，我们的研究表明，非同义SNP rs1126497可能是NSCLC患者的潜在预后标志物。

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