Communication of γ Phage Lysin plyG Enzymes Binding toward SrtA for Inhibition of Bacillus Anthracis: Protein–Protein Interaction and Molecular Dynamics Study

Chandrabose Selvaraj; Ramanathan Bharathi Priya; Sanjeev Kumar Singh

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Communication of γ Phage Lysin plyG Enzymes Binding toward SrtA for Inhibition of Bacillus Anthracis: Protein–Protein Interaction and Molecular Dynamics Study

机译：γ噬菌体溶素plyG酶结合SrtA抑制炭疽芽孢杆菌的交流：蛋白-蛋白质相互作用和分子动力学研究

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Bacillus anthracis is a pathogenic, Gram-positive bacterium which chiefly affects the livestock of animals and humans through acute disease anthrax. All around the globe this bio-threat organism damages millions of lives in every year and also most of the drugs were not responding properly in inhibition against this diseased pathogen. In recent development, phage therapy is considered as alternative solution to treat this serious infectious disease. In this study, we elucidated the binding of γ phage lysin plyG enzymes toward the SrtA along with its activator peptide LPXTG. Through protein–protein docking and molecular dynamics simulation studies, we showed the distinguished structure complementarity of SrtA and plyG complex. Especially, MD simulation relates strong and stable interaction occurs between the protein complex structures. These results suggest that additional experimental studies on our approach will lead to availability of better inhibitor against the SrtA.

机译：炭疽杆菌是一种致病性革兰氏阳性细菌，主要通过急性疾病炭疽病影响动物和人类的家畜。在全球范围内，这种生物威胁生物每年造成数百万人的生命损失，而且大多数药物在抑制这种病原体方面均没有做出适当的反应。在最近的发展中，噬菌体疗法被认为是治疗这种严重传染病的替代解决方案。在这项研究中，我们阐明了γ噬菌体溶素plyG酶与SrtA及其激活肽LPXTG的结合。通过蛋白质-蛋白质对接和分子动力学模拟研究，我们显示了SrtA和plyG复合物的显着结构互补性。特别地，MD模拟涉及蛋白质复合物结构之间发生强而稳定的相互作用。这些结果表明，关于我们方法的其他实验研究将导致可获得更好的抗SrtA抑制剂。

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《Cell communication & adhesion》 |2014年第5期|共9页
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Chandrabose Selvaraj; Ramanathan Bharathi Priya; Sanjeev Kumar Singh;
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中图分类细胞生物学;
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1. Communication of gamma Phage Lysin plyG Enzymes Binding toward SrtA for Inhibition of Bacillus Anthracis : Protein-Protein Interaction and Molecular Dynamics Study [J] . Selvaraj Chandrabose, Priya Ramanathan Bharathi, Singh Sanjeev Kumar Cell communication & adhesion . 2014,第1a6期

机译：γ噬菌体溶素plyG酶结合SrtA抑制炭疽芽胞杆菌的交流：蛋白质-蛋白质相互作用和分子动力学研究
2. Identification of the amino acid residues critical for specific binding of the bacteriolytic enzyme of gamma-phage, PlyG, to Bacillus anthracis. [J] . Kikkawa H, Fujinami Y, Suzuki S, Biochemical and Biophysical Research Communications . 2007,第3期

机译：鉴定对于γ-噬菌体PlyG的细菌分解酶与炭疽芽孢杆菌特异性结合至关重要的氨基酸残基。
3. Identification of the amino acid residues critical for specific binding of the bacteriolytic enzyme of gamma-phage, PlyG, to Bacillus anthracis. [J] . Kikkawa H, Fujinami Y, Suzuki S, Biochemical and Biophysical Research Communications . 2007,第3期

机译：鉴定对于γ-噬菌体PlyG的细菌分解酶与炭疽芽孢杆菌特异性结合至关重要的氨基酸残基。
4. Interaction of Bacterial O-Antigen Polysaccharides with Tailspike Protein of Shigella Phage Sf6: A Molecular Dynamics Study [C] . Kang Y., Barbirz S., Lipowsky R. International Carbohydrate Symposium . 2013

机译：细菌O-抗原多糖与血花菌噬菌体SF6尾刺蛋白的相互作用：分子动力学研究
5. Structure/function studies of membrane proteins: From molecular modeling and ligand binding to protein -protein interactions of the dopamine transporter [D] . Beuming, Thijs. 2007

机译：膜蛋白的结构/功能研究：从分子模型和配体结合到多巴胺转运蛋白的蛋白-蛋白相互作用
6. Gamma-phage lysin PlyG sequence-based synthetic peptides coupled with Qdot-nanocrystals are useful for developing detection methods for Bacillus anthracis by using its surrogates B. anthracis-Sterne and B. cereus-4342 [O] . Shilpakala Sainathrao, Ketha V Krishna Mohan, Chintamani Atreya 2009

机译：基于γ噬菌体溶素PlyG序列的合成肽与Qdot纳米晶体的结合可用于开发炭疽芽孢杆菌的检测方法方法是使用其替代物炭疽芽孢杆菌-Sterne和蜡状芽孢杆菌-4342
7. Communication of γ Phage Lysin plyG Enzymes Binding toward SrtA for Inhibition ofBacillus Anthracis: Protein–Protein Interaction and Molecular Dynamics Study [O] . Chandrabose Selvaraj, Ramanathan Bharathi Priya, Sanjeev Kumar Singh 2014

机译：γ噬菌体溶胶酶与胰腺炎抑制抑制作用的γ噬菌体溶酶蛋白酶的通信：蛋白质 - 蛋白质相互作用和分子动力学研究
8. Low-Molecular-Weight, Cobalt-Binding Proteins from Saccharomyces Cerevisiae and Bacillus Subtilis [R] . Leeper, S. A., Wolfram, J. H., Ward, T. E. 1985

机译：来自酿酒酵母和枯草芽孢杆菌的低分子量钴结合蛋白

Communication of γ Phage Lysin plyG Enzymes Binding toward SrtA for Inhibition of Bacillus Anthracis: Protein–Protein Interaction and Molecular Dynamics Study

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