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首页> 外文期刊>Cell communication & adhesion >Prognostic Value of the Tumour-Infiltrating Dendritic Cells in Colorectal Cancer: A Systematic Review
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Prognostic Value of the Tumour-Infiltrating Dendritic Cells in Colorectal Cancer: A Systematic Review

机译：肿瘤浸润性树突状细胞在结直肠癌中的预后价值：系统评价。

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Dendritic cells (DCs) either boost the immune system (enhancing immunity) or dampen it (leading to tolerance). This dual effect explains their vital role in cancer development and progression. DCs have been tested as a predictor of outcomes for cancer progression. Eight studies evaluated tumour-infiltrating DCs (TIDCs) as a predictor for colorectal cancer (CRC) outcomes. The detection of TIDCs has not kept pace with the increased knowledge about the identification of DC subsets and their maturation status. For that reason, it is difficult to draw a conclusion about the performance of DCs as a predictor of outcome for CRC. In this review, we comprehensively examine the evidence for the in situ immune response due to DC infiltration, in predicting outcome in primary CRC and how such information may be incorporated into routine clinical assessment.
机译：树突状细胞（DC）可以增强免疫系统（增强免疫力）或抑制免疫系统（导致耐受性）。这种双重作用解释了它们在癌症发展和进展中的重要作用。已经测试了DC作为癌症进展结果的预测指标。八项研究评估了肿瘤浸润性DC（TIDC）作为大肠癌（CRC）结局的预测因子。 TIDC的检测跟不上关于DC子集及其成熟状态的识别知识的增长。因此，很难就DC作为CRC结果的预测指标得出结论。在这篇综述中，我们全面检查了DC浸润引起的原位免疫反应的证据，以预测原发性CRC的结局以及如何将这些信息纳入常规临床评估。

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