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p107 in the public eye: an Rb understudy and more

机译：公众视野中的p107：Rb研究不足等

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摘要

p107 and its related family members Rb and p130 are critical regulators of cellular proliferation and tumorigenesis. Due to the extent of functional overlap within the Rb family, it has been difficult to assess which functions are exclusive to individual members and which are shared. Like its family members, p107 can bind a variety of cellular proteins to affect the expression of many target genes during cell cycle progression. Unlike Rb and p130, p107 is most highly expressed during the G1 to S phase transition of the cell cycle in actively dividing cells and accumulating evidence suggests a role for p107 during DNA replication. The specific roles for p107 during differentiation and development are less clear, although emerging studies suggest that it can cooperate with other Rb family members to control differentiation in multiple cell lineages. As a tumor suppressor, p107 is not as potent as Rb, yet studies in knockout mice have revealed some tumor suppressor functions in mice, depending on the context. In this review, we identify the unique and overlapping functions of p107 during the cell cycle, differentiation, and tumorigenesis.
机译：p107及其相关家族成员Rb和p130是细胞增殖和肿瘤发生的关键调节剂。由于Rb家族内部功能重叠的程度，很难评估哪些功能是单个成员专有的，哪些是共享的。与其家族成员一样，p107可以结合多种细胞蛋白，从而在细胞周期进程中影响许多靶基因的表达。与Rb和p130不同，p107在主动分裂细胞的细胞周期从G1期到S期的过渡过程中表达最高，并且越来越多的证据表明p107在DNA复制过程中发挥了作用。尽管新兴研究表明p107可以与其他Rb家族成员合作以控制多种细胞谱系中的分化，但p107在分化和发育过程中的具体作用尚不清楚。作为一种抑癌基因，p107不如Rb强大，但根据基因环境，对基因敲除小鼠的研究表明其在小鼠体内具有某些抑癌功能。在这篇综述中，我们确定了p107在细胞周期，分化和肿瘤发生过程中的独特和重叠功能。

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