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首页> 外文期刊>Cellular Physiology and Biochemistry >Syzygium cumini Extract Decrease Adenosine Deaminase, 5′Nucleotidase Activities and Oxidative Damage in Platelets of Diabetic Patients
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Syzygium cumini Extract Decrease Adenosine Deaminase, 5′Nucleotidase Activities and Oxidative Damage in Platelets of Diabetic Patients

机译：孜孜孜然提取物降低糖尿病患者血小板中的腺苷脱氨酶，5'核酸酶活性和氧化损伤

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Diabetes mellitus, a chronic metabolic disorder, has assumed epidemic proportions and its long-term complications can have devastating consequences. The oxidative stress in diabetes was greatly increased due to prolonged exposure to hyperglycemia and impairment of oxidant/antioxidant equilibrium. iSyzygium cumini/i is being widely used to treat diabetes by the traditional practitioners over many centuries. Adenosine deaminase (ADA) and 5′-Nucleotidase (5′NT) are enzymes of purine nucleoside metabolism that play an important role in the regulation of adenosine (Ado) levels. In this study, we investigated the effect of iSyzygium cumini/i aqueous leaves extract (ASc) on ADA and 5′NT activities and on parameters of oxidative stress under iin vitro/i conditions, using platelets of patients with Type 2 diabetes mellitus. Platelet-Rich Plasma (PRP) was assayed by ADA, 5′NT, Catalase (CAT), Superoxide Dismutase (SOD) activities and Thiobarbituric acid reactive substances (TBARS) levels. We observed that ADA, 5′NT activities and TBARS levels were significantly higher when compared to the control group, and ASc (100 and 200 µg/mL) prevented these effects. Our study demonstrates that ASc was able to remove oxidant species generated in diabetic conditions and modulates in the Ado levels. Then, ASc may promote a compensatory response in platelet function, improving the susceptibility-induced by the diabetes mellitus.
机译：糖尿病是一种慢性代谢性疾病，已呈流行趋势，其长期并发症可能造成毁灭性后果。由于长时间暴露于高血糖症和氧化/抗氧化平衡受损，糖尿病中的氧化应激大大增加。数百年来， Syzygium cumini 被传统医生广泛用于治疗糖尿病。腺苷脱氨酶（ADA）和5'-核苷酸酶（5'NT）是嘌呤核苷代谢的酶，在调节腺苷（Ado）水平中起重要作用。在这项研究中，我们研究了 Syzygium cumini 水叶提取物（ASc）在体外条件下对ADA和5'NT活性以及氧化应激参数的影响，使用2型糖尿病患者的血小板。通过ADA，5'NT，过氧化氢酶（CAT），超氧化物歧化酶（SOD）活性和硫代巴比妥酸反应性物质（TBARS）含量测定富血小板血浆（PRP）。我们观察到，与对照组相比，ADA，5'NT活性和TBARS水平明显更高，而ASc（100和200 µg / mL）阻止了这些作用。我们的研究表明，ASc能够去除糖尿病条件下产生的氧化剂并调节Ado水平。然后，ASc可以促进血小板功能的代偿性反应，从而改善糖尿病诱发的易感性。

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