Sphingosine 1-Phosphate in Renal Diseases

Alexander Koch; Josef Pfeilschifter; Andrea Huwiler

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Sphingosine 1-Phosphate in Renal Diseases

机译：鞘氨醇1-磷酸在肾脏疾病中的作用

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Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about the physiological and pathophysiological functions of S1P in this organ have been raised. In this review, we summarize the current state of knowledge about S1P-mediated functions in the kidney. A special focus is put on S1P modulated signal transduction in renal glomerular and tubular cells and consequences for the development and treatment of several kidney diseases, diabetic nephropathy, glomerulonephritis, ischemia-reperfusion injury, as well as for Wilms tumor progression.

机译：由于鞘氨醇1-磷酸酯（S1P）具有很高的生物活性，因此它是治疗多种疾病的有吸引力的靶标。由于在肾脏中证实了鞘氨醇激酶以及S1P受体的表达，因此已经提出了关于S1P在该器官中的生理和病理生理功能的问题。在这篇综述中，我们总结了有关肾脏中S1P介导的功能的当前知识状态。特别关注的是肾小球和肾小管细胞中S1P调制的信号转导及其对几种肾脏疾病，糖尿病性肾病，肾小球性肾炎，缺血再灌注损伤以及Wilms肿瘤进展的发展和治疗的后果。

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《Cellular Physiology and Biochemistry》 |2013年第6期|共16页
作者
Alexander Koch; Josef Pfeilschifter; Andrea Huwiler;
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中图分类细胞生物物理学;
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Sphingosine 1-phosphateGlomerulonephritisDiabetic nephropathyIschemia-reperfusion injuryWilms tumorKidney disease;

机译：1-磷酸鞘氨醇肾小球肾炎糖尿病肾病缺血再灌注损伤Wilms肿瘤肾脏疾病;

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1. Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease [J] . Johnatan Ceccom, Najat Loukh, Valérie Lauwers-Cances, Acta Neuropathologica Communications . 2014,第1期

机译：鞘氨醇激酶-1的减少和鞘氨醇1-磷酸裂解酶表达的增强表明阿尔茨海默氏病中鞘氨醇1-磷酸信号的表达失调
2. Synthesis of fluorescence-Labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior. [J] . Hakogi T, Shigenari T, Katsumura S, Bioorganic and Medicinal Chemistry Letters . 2003,第4期

机译：荧光标记的鞘氨醇和1-磷酸鞘氨醇的合成;鞘氨醇和1-磷酸鞘氨醇行为的有效工具。
3. Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors [J] . Biochimica et Biophysica Acta. Molecular and cell biology of Lipids . 2013,第1期

机译：针对疾病中的鞘氨醇激酶/鞘氨醇1-磷酸途径：鞘氨醇激酶抑制剂综述
4. Sphingosine 1-phosphate receptor three regulates implant arteriogenesis by recruitment and localization of anti-inflammatory monocytes to surrounding microvessels [C] . Anthony O. Awojoodu, Lauren S. Anderson, Kyle Martin, Society for Biomaterials annual meeting and exposition . 2013

机译：1-磷酸鞘氨醇受体3通过将消炎单核细胞募集和定位到周围微血管来调节植入物的动脉生成
5. Sphingosine Kinase-2/Sphingosine 1-Phosphate Signaling Regulates Telomerase in Lung Cancer. [D] . Panneer Selvam, Shanmugam. 2013

机译：Sphingosine Kinase-2 / Sphingosine 1-磷酸信号调节肺癌中的端粒酶。
6. Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease [O] . Johnatan Ceccom, Najat Loukh, Valérie Lauwers-Cances, 2014

机译：鞘氨醇激酶-1的减少和鞘氨醇1-磷酸裂解酶表达的增强表明阿尔茨海默氏病中鞘氨醇1-磷酸信号的表达失调
7. Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease [O] . Johnatan Ceccom, Najat Loukh, Valérie Lauwers-Cances, 2014

机译：鞘氨醇激酶-1的减少和鞘氨醇1-磷酸裂解酶表达的增强表明阿尔茨海默氏病中鞘氨醇1-磷酸信号的表达失调

Sphingosine 1-Phosphate in Renal Diseases

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