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Underlying Signaling Pathways and Therapeutic Applications of Pulsed Electromagnetic Fields in Bone Repair

机译：脉冲电磁场​​在骨修复中的潜在信号通路和治疗应用

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Pulsed electromagnetic field (PEMF) stimulation, as a prospective, noninvasive, and safe physical therapy strategy to accelerate bone repair has received tremendous attention in recent decades. Physical PEMF stimulation initiates the signaling cascades, which effectively promote osteogenesis and angiogenesis in an orchestrated spatiotemporal manner and ultimately enhance the self-repair capability of bone tissues. Considerable research progresses have been made in exploring the underlying cellular and subcellular mechanisms of PEMF promotion effect in bone repair. Moreover, the promotion effect has shown strikingly positive benefits in the treatment of various skeletal diseases. However, many preclinical and clinical efficacy evaluation studies are still needed to make PEMFs more effective and extensive in clinical application. In this review, we briefly introduce the basic knowledge of PEMFs on bone repair, systematically elaborate several key signaling pathways involved in PEMFs-induced bone repair, and then discuss the therapeutic applications of PEMFs alone or in combination with other available therapies in bone repair, and evaluate the treatment effect by analyzing and summarizing recent literature.
机译：脉冲电磁场​​（PEMF）刺激作为一种前瞻性，无创且安全的物理疗法，可以促进骨骼修复，在最近几十年中受到了极大的关注。物理PEMF刺激启动信号级联反应，以有序的时空方式有效地促进成骨和血管生成，并最终增强骨组织的自我修复能力。在探索PEMF促进骨修复的潜在细胞和亚细胞机制方面，已经取得了相当大的研究进展。而且，促进作用在各种骨骼疾病的治疗中显示出惊人的积极益处。但是，仍需要进行许多临床前和临床功效评估研究，以使PEMF在临床应用中更加有效和广泛。在这篇综述中，我们简要介绍了PEMFs在骨修复中的基本知识，系统地阐述了PEMFs诱导的骨修复中涉及的几个关键信号通路，然后讨论了PEMFs单独或与其他可用疗法联合用于骨修复的治疗应用，通过分析和总结最近的文献来评估治疗效果。

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