...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular Physiology and Biochemistry >Delivery of Placenta-Derived Mesenchymal Stem Cells Ameliorates Ischemia Induced Limb Injury by Immunomodulation
【24h】

Delivery of Placenta-Derived Mesenchymal Stem Cells Ameliorates Ischemia Induced Limb Injury by Immunomodulation

机译：胎盘来源的间充质干细胞的传递通过免疫调节改善了缺血引起的肢体损伤。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

biBackground /i/bPeripheral artery disease (PAD) is a major health burden in the world. Stem cell-based therapy has emerged as an attractive treatment option in regenerative medicine. In this study, we sought to test the hypothesis that stem cell-based therapy can ameliorate ischemia induced limb injury. biMethods /i/bWe isolated mesenchymal stem cells derived from human placentas (PMSCs) and intramuscularly transplanted them into injured hind limbs. Treatment with PMSCs reduced acute muscle fibers apoptosis induced by ischemia. biResults /i/bPMSC treatment significantly enhanced regeneration of the injured hind limb by reducing fibrosis and enhancing running capacity when the animals were subjected to treadmill training. Mechanistically, injected PMSCs can modulate acute inflammatory responses by reducing neutrophil and macrophage infiltration following limb ischemia. ELISA assays further confirmed that PMSC treatment can also reduce pro-inflammatory cytokines, TNF-α and IL-6, and enhance anti-inflammatory cytokine, IL-10 at the injury sites. biConclusion /i/bTaken together, our results demonstrated that PMSCs can be a potential effective therapy for treatment of PAD via immunomodulation.
机译：背景 周围动脉疾病（PAD）是世界上的主要健康负担。在再生医学中，基于干细胞的治疗已成为一种有吸引力的治疗选择。在这项研究中，我们试图检验基于干细胞疗法可以改善局部缺血引起的肢体损伤的假说。 方法 我们分离了源自人胎盘（PMSC）的间充质干细胞，并将其肌肉内移植到了受伤的后肢中。 PMSCs的治疗减少了缺血引起的急性肌纤维凋亡。 结果 当对动物进行跑步训练时，PMSC处理可通过减少纤维化和增强运动能力来显着增强受伤后肢的再生。从机制上讲，注射的PMSC可通过减少肢体缺血后的嗜中性粒细胞和巨噬细胞浸润来调节急性炎症反应。 ELISA分析进一步证实，PMSC治疗还可以减少损伤部位的促炎细胞因子TNF-α和IL-6，并增强抗炎细胞因子IL-10。 结论 我们的研究结果表明，PMSCs可能是通过免疫调节治疗PAD的潜在有效疗法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号