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首页> 外文期刊>Cellular Physiology and Biochemistry >Gastric Neuroendocrine Tumors (G-Nets): Incidence, Prognosis and Recent Trend Toward Improved Survival
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Gastric Neuroendocrine Tumors (G-Nets): Incidence, Prognosis and Recent Trend Toward Improved Survival

机译：胃神经内分泌肿瘤（G-Nets）：发病率，预后和近期生存趋势

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Background/Aims Gastric neuroendocrine tumors (G-NETs) are uncommon neoplasms that can present with or without clinical symptoms. In this study, we evaluated the incidence, prognosis, and temporal trends of G-NETs. Methods We analyzed all cases of G-NETs registered in the Surveillance, Epidemiology, and End Results (SEER) database from 1973 to 2014. Incidence was estimated by age and joinpoint analyses. Survival rates were calculated and survival trends over time were evaluated. Results A total of 3740 eligible patients were enrolled in the study. G-NETs incidence increased from 0.31 per 1 000 000 patients in 1975 to 4.85 in 2014, with an annual percentage changes (APCs) of 8.9% (95% confidence interval [CI] = 7.7% to 10.21%, P < 0.001, t test (29) from 1975 to 2001 and 3.6% from 2002 to 2014 (95% CI= 2.3% to 4.9%, P < 0.001). For cases diagnosed between 1973 and 1982, five-year survival was 62.8% ± 7.0% (Standard error, SE) and increased to 86.7% ± 0.7% for cases diagnosed between 2003 and 2012 (P < 0.001). Years of diagnosis, gender, age at diagnosis, marital status, grade, tumor size, tumor stage, and surgery performed or not were the strongest predictors of worse survival in both univariate and multivariate analysis (P<0.05). Conclusion G-NETs are uncommon neoplasms but the incidence is growing. Survival has improved in the past decades. Years of diagnosis, gender, age at diagnosis, marital status, grade, tumor size, tumor stage, and surgery status predict survival in patients with G-NETs.
机译：背景/目的胃神经内分泌肿瘤（G-NETs）是罕见的肿瘤，可出现或不出现临床症状。在这项研究中，我们评估了G-NET的发生率，预后和时间趋势。方法我们分析了1973年至2014年在“监视，流行病学和最终结果（SEER）”数据库中注册的所有G-NET病例。通过年龄和连接点分析估算了发病率。计算存活率并评估随时间的存活趋势。结果共有3740名符合条件的患者参加了研究。 G-NET的发生率从1975年的每1000万例患者中的0.31个增加到2014年的4.85个，年百分比变化（APC）为8.9％（95％置信区间[CI] = 7.7％至10.21％，P＆＃x3c; 1975年至2001年的0.001，t检验（29）和2002年至2014年的3.6％（95％CI = 2.3％至4.9％，P＆＃x3c; 0.001）。对于1973年至1982年之间诊断的病例，其五年生存率为62.8％±7.0％（标准误，SE），对于2003年至2012年之间确诊的病例（P＆＃x3c; 0.001）增加至86.7％±0.7％（诊断年龄，性别，诊断年龄，婚姻状况，等级，在单因素和多因素分析中，肿瘤的大小，肿瘤的分期和是否进行手术是生存率降低的最强预测因素（P＆＃x3c; 0.05）结论G-NETs是罕见的肿瘤，但发病率正在增长。诊断的年限，性别，诊断年龄，婚姻状况，等级，肿瘤大小，肿瘤分期和手术状况可预测G-NETs患者的生存率。

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